INT142482

Context Info Confidence 0.28 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.17 Pain Relevance 0.22

unfolded protein binding (HSPA5) endoplasmic reticulum (HSPA5) ATPase activity (HSPA5) nucleus (HSPA5) protein binding, bridging (HSPA5)

Anatomy Link Frequency reticulum 2 HSPA5 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 3 84.24

Disease Link Frequency Relevance Heat Stress 2 97.92 Toxicity 1 97.16 Apoptosis 7 92.28 Renal Cancer 4 88.16 INFLAMMATION 1 69.16 Cancer 1 65.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.

Positive_regulation (increased) of Positive_regulation (activation) of GRP78 in reticulum associated with stress

1) Confidence 0.28 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.17 Pain Relevance 0.22

General Comments

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