INT142483

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.39
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DDIT3) nucleus (DDIT3) cell cycle (DDIT3)
DNA binding (DDIT3) transcription factor binding (DDIT3)
Anatomy Link Frequency
arms 12
reticulum 4
liver 2
MCF-7 2
DDIT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 43 99.98 Very High Very High Very High
cINOD 7 90.04 High High
Inflammation 50 89.56 High High
ischemia 2 85.56 High High
COX2 2 68.16 Quite High
agonist 33 50.00 Quite Low
vincristine 12 42.24 Quite Low
alcohol 5 32.24 Quite Low
cytokine 35 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 138 99.98 Very High Very High Very High
Apoptosis 107 99.80 Very High Very High Very High
Lung Cancer 1 99.44 Very High Very High Very High
Death 74 98.20 Very High Very High Very High
Hepatitis C Virus Infection 27 97.68 Very High Very High Very High
Breast Cancer 1 97.60 Very High Very High Very High
Toxicity 26 97.16 Very High Very High Very High
Alcoholic Liver Diseases 19 92.80 High High
Chronic Hepatitis 4 92.40 High High
Cancer 28 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of Gene_expression (levels) of GADD153 associated with stress and qutenza
1) Confidence 0.67 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (result) of Gene_expression (over) of CHOP in arms
2) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.24 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (superiority) of Gene_expression (over) of R-CHOP in arms
3) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.23 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (over) of Gene_expression (over) of CHOP in arms
4) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.23 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (result) of Gene_expression (over) of R-CHOP in arms
5) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.24 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (over) of Gene_expression (over) of R-CHOP in arms
6) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.23 Pain Relevance 0
Since the number of adverse events was comparable in both treatment arms, a significant superiority of R-CHOP over CHOP alone was the major result of this trial.20
Positive_regulation (superiority) of Gene_expression (over) of CHOP in arms
7) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886316 Disease Relevance 0.24 Pain Relevance 0
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of Gene_expression (levels) of Chop associated with stress and qutenza
8) Confidence 0.49 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
The JNK inhibitor SP600125 down-regulated the expression of IRE1, Chop, and LC3II induced by DHC, thapsigargin, and MG132 [N-benzoyloxycarbonyl (Z)-Leu-Leu-leucinal].
Positive_regulation (induced) of Gene_expression (expression) of Chop
9) Confidence 0.49 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19139269 Disease Relevance 0.45 Pain Relevance 0.46
Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor.
Positive_regulation (induced) of Gene_expression (expression) of CHOP associated with stress and apoptosis
10) Confidence 0.49 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.28 Pain Relevance 0.18
Immunostaining and confocal microscopic analysis also showed that capsaicin promoted cytoplasmic GADD153 expression and GRP78 nuclear translocation.
Positive_regulation (promoted) of Gene_expression (expression) of GADD153 associated with qutenza
11) Confidence 0.43 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19331147 Disease Relevance 0.32 Pain Relevance 0.88
With respect to HCV, several studies have shown that HCV-related proteins, including either core proteins as well as E1 and E2 proteins of the envelope, are able to induce overexpression of C/EBP homologous protein (CHOP) via the UPR response, ER depletion of calcium, and apoptosis in liver cells (HCV replicon cells) [215,216].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CHOP in liver associated with apoptosis and hepatitis c virus infection
12) Confidence 0.29 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.39 Pain Relevance 0
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Positive_regulation (activation) of Gene_expression (expression) of CHOP in reticulum associated with stress
13) Confidence 0.28 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.16 Pain Relevance 0.22
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Positive_regulation (increased) of Gene_expression (expression) of CHOP in reticulum associated with stress
14) Confidence 0.28 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.17 Pain Relevance 0.22
Apoptosis induced by TRO in human MCF-7 breast carcinoma cells has been associated with induction of GADD45 gene expression [85] while growth inhibition has been correlated to overexpression of another DNA damage gene, GADD153, in nonsmall lung carcinoma cells [86].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GADD153 in MCF-7 associated with lung cancer, breast cancer and apoptosis
15) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.75 Pain Relevance 0.03

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