INT142488

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.09
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chkb)
Anatomy Link Frequency
upper 4
Chkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
Central grey 20 98.80 Very High Very High Very High
Neurotransmitter 14 98.20 Very High Very High Very High
opiate 6 95.92 Very High Very High Very High
antagonist 10 93.24 High High
Serotonin 2 92.68 High High
gABA 2 90.96 High High
Glutamate 4 90.68 High High
Dopamine 2 90.00 High High
Central nervous system 6 89.36 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 98.80 Very High Very High Very High
Myocardial Infarction 15 93.48 High High
Injury 18 93.44 High High
Pain 112 87.92 High High
Reperfusion Injury 29 83.56 Quite High
INFLAMMATION 19 83.12 Quite High
Pressure And Volume Under Development 9 80.48 Quite High
Hemorrhage 3 79.92 Quite High
Meningitis 14 79.52 Quite High
Natriuresis 2 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study found that the increased ratios of S/L, LDH and CK, and the decreased levels of TP in groups M, C and group K compared to group S in the survival rats.
Positive_regulation (increased) of Gene_expression (ratios) of CK
1) Confidence 0.23 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.25 Pain Relevance 0.25
The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid.
Positive_regulation (elevated) of Gene_expression (concentrations) of L-Ek associated with dopamine, glutamate, gaba, neurotransmitter, enkephalin, central grey and serotonin
2) Confidence 0.10 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17341433 Disease Relevance 0.75 Pain Relevance 1.51
The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid.
Positive_regulation (elevated) of Gene_expression (concentrations) of M-Ek associated with dopamine, glutamate, gaba, neurotransmitter, enkephalin, central grey and serotonin
3) Confidence 0.08 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17341433 Disease Relevance 0.81 Pain Relevance 1.55
Troponin as well as CK-MB levels were not elevated in any of the samples tested.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of CK-MB
4) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475607 Disease Relevance 0.32 Pain Relevance 0
Forty percent of patients from clinical studies (largely open label) had serum creatine kinase (CK) levels above the upper limit of normal, and 11% had CK levels that were ?
Positive_regulation (were) of Gene_expression (levels) of CK in upper
5) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.38 Pain Relevance 0.61
Forty percent of patients from clinical studies (largely open label) had serum creatine kinase (CK) levels above the upper limit of normal, and 11% had CK levels that were ?
Positive_regulation (had) of Gene_expression (levels) of CK in upper
6) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.38 Pain Relevance 0.61
mg/kg ISO subcutaneously) showed significant increase (P < .001) in serum levels of CK-MB, LDH, GOT, ALK-P and uric acid compared to Group I (vehicle-treated rats injected with normal saline 2?
Positive_regulation (levels) of Gene_expression (levels) of CK-MB
7) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952329 Disease Relevance 0.18 Pain Relevance 0

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