INT1425

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Context Info
Confidence 0.58
First Reported 1977
Last Reported 2011
Negated 5
Speculated 4
Reported most in Abstract
Documents 143
Total Number 147
Disease Relevance 51.32
Pain Relevance 65.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
neurons 11
interneurons 6
nociceptors 5
lamina 4
endothelial cells 4
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 2007 100.00 Very High Very High Very High
antagonist 688 100.00 Very High Very High Very High
Pain 408 100.00 Very High Very High Very High
agonist 223 100.00 Very High Very High Very High
opioid receptor 96 100.00 Very High Very High Very High
chemokine 72 100.00 Very High Very High Very High
calcitonin gene related peptide 66 100.00 Very High Very High Very High
gABA 61 100.00 Very High Very High Very High
substance P 57 100.00 Very High Very High Very High
Opioid 51 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 374 100.00 Very High Very High Very High
Nociception 212 100.00 Very High Very High Very High
Targeted Disruption 570 99.98 Very High Very High Very High
Bacillus Anthracis Infection 14 99.98 Very High Very High Very High
Ovarian Cancer 39 99.86 Very High Very High Very High
Glioma 1 99.86 Very High Very High Very High
Cancer 523 99.84 Very High Very High Very High
Neuropathic Pain 329 99.84 Very High Very High Very High
Endometriosis (extended) 54 99.72 Very High Very High Very High
Ganglion Cysts 760 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to investigate the antinociceptive interaction of a clinically used opioid, pentazocine which produces its analgesic effect mainly through kappa receptors, with some calcium channel blockers (CCBs, viz.
Gene_expression (produces) of receptors associated with fortral, calcium channel, analgesic, opioid and antinociceptive
1) Confidence 0.58 Published 2000 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 10941612 Disease Relevance 0.22 Pain Relevance 1.05
Opiate B receptors located on adrenergic nerve terminals are present in the cat nictitating membrane and in the brain.
Gene_expression (present) of receptors in brain associated with opiate
2) Confidence 0.49 Published 1977 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 196268 Disease Relevance 0.19 Pain Relevance 0.87
Both noncompetitively inhibit NMDA receptors, yet there is little evidence that these drugs affect GABA(A) receptors, the primary target of most anesthetics. alpha6beta2/3delta receptors are subtypes of the GABA(A) receptor family and are abundantly expressed in granular neurons within the adult cerebellum.
Gene_expression (expressed) of receptors in cerebellum associated with gaba and nmda receptor
3) Confidence 0.37 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.26 Pain Relevance 0.69
What aspects of learning EphA receptors mediate have not been studied?
Gene_expression (aspects) of receptors
4) Confidence 0.34 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10701657 Disease Relevance 0.39 Pain Relevance 0.25
This antagonism is probably related to their partial agonistic properties of the alpha(7) receptors.
Spec (partial) Gene_expression (properties) of receptors
5) Confidence 0.31 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044748 Disease Relevance 0.20 Pain Relevance 1.04
Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice.
Gene_expression (produce) of receptors associated with cocaine
6) Confidence 0.25 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11426838 Disease Relevance 0.07 Pain Relevance 0.47
Opioid peptides modulate immune responses via ligation to classical opioid receptors (mu, delta and kappa), expressed on immune cells, or in an indirect fashion via the central nervous system.
Gene_expression (expressed) of receptors in central nervous system associated with central nervous system, opioid receptor and opioid
7) Confidence 0.23 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15829417 Disease Relevance 0.31 Pain Relevance 0.31
CAPER, PIMT and CoAA were identified in yeast two-hybrid screens to interact with NCoA6 (Figure 2).
Gene_expression (identified) of CAPER
8) Confidence 0.22 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Mouse CAPER (HCC1.3) was reported to enhance activation of ER?
Gene_expression (enhance) of CAPER in Mouse
9) Confidence 0.22 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In the current study a fluorescein isothiocyanate-conjugated naltrexone (FITC-NTX) derivative in the absence or presence of naltrexone, as a competitor, was used to detect opioid receptors on thymocytes and then on splenocytes of normal and tumor bearing Balb/c mice.
Gene_expression (detect) of receptors in thymocytes associated with cancer and opioid receptor
10) Confidence 0.20 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15829417 Disease Relevance 0.44 Pain Relevance 0.32
The combination of immunofluorescent technique and flow cytometry has proven to be sensitive methods for detection of opioid receptors on leukocytes.
Gene_expression (detection) of receptors in leukocytes associated with opioid receptor
11) Confidence 0.20 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15829417 Disease Relevance 0.37 Pain Relevance 0.31
Heroin produced antinociception in the tail flick test through mu receptors in the brain of ICR and CD-1 mice, a response inhibited by 3-O-methylnaltrexone.
Gene_expression (produced) of receptors in brain associated with antinociception and tail-flick
12) Confidence 0.20 Published 2000 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10806416 Disease Relevance 0 Pain Relevance 0.79
DAMPGO (Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5), DPDPE (D-Pen2, D-Pen5, enkephalin) and U50-488H, opioid agonists highly selective for mu, delta and kappa receptors, respectively, were administered alone i.c.v. or intrathecally (i.t.) or in combination (i.c.v. plus i.t.) to determine ED50 values for the tail-flick response in mice.
Gene_expression (selective) of receptors in tail associated with mu agonist, tail-flick and enkephalin
13) Confidence 0.18 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2567350 Disease Relevance 0 Pain Relevance 1.15
Taken together, these results showed that, direct fluorescence staining failed to stain opioid receptors expressed on lymphocytes.
Gene_expression (expressed) of receptors in lymphocytes associated with opioid receptor
14) Confidence 0.18 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15829417 Disease Relevance 0.44 Pain Relevance 0.24
Adaptive changes in the expression of central opioid receptors in mice lacking the dopamine D2 receptor gene.
Gene_expression (expression) of receptors associated with dopamine and opioid receptor
15) Confidence 0.17 Published 2008 Journal Neuroscience Section Title Doc Link 18424009 Disease Relevance 0.08 Pain Relevance 0.51
On the basis of numerous studies that have described interactions between the dopaminergic and opioidergic systems, we have investigated whether genetic deletion of dopamine D2 receptors (D2R) might influence the expression of central opioid receptors.
Gene_expression (expression) of receptors associated with dopamine and opioid receptor
16) Confidence 0.17 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.09 Pain Relevance 0.42
These behavioral changes were accompanied after surgery by an increase of c-Fos expression and by an overexpression of mu-opioid and cannabinoid CB1 and CB2 receptors in the spinal cord and the dorsal hind paw skin.
Gene_expression (overexpression) of receptors in paw associated with cannabinoid, opioid and spinal cord
17) Confidence 0.15 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16511871 Disease Relevance 0.95 Pain Relevance 1.28
Pre-incubation with the highly selective delta-receptor antagonist ICI 174864 concentration-dependently protected delta-receptors from inactivation, but the same concentrations similarly protected mu receptors.
Gene_expression (protected) of receptors associated with antagonist
18) Confidence 0.12 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2829013 Disease Relevance 0 Pain Relevance 0.32
Cross-protection of mu and delta opioid receptors in the mouse vas deferens.
Gene_expression (Cross-protection) of receptors in vas deferens associated with delta opioid receptors
19) Confidence 0.12 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2829013 Disease Relevance 0 Pain Relevance 0.31
Involvement of spinal kappa opioid receptors in the antinociception produced by intrathecally administered corticotropin-releasing factor in mice.
Gene_expression (produced) of receptors in spinal associated with antinociception, narcan and kappa opioid receptor
20) Confidence 0.12 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2166788 Disease Relevance 0.18 Pain Relevance 0.89

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