INT142500

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.27
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
nerve 2
urothelial cells 2
neurons 1
reproductive organs 1
spleen 1
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 2 98.86 Very High Very High Very High
dorsal root ganglion 27 98.40 Very High Very High Very High
c fibre 7 96.08 Very High Very High Very High
allodynia 114 95.36 Very High Very High Very High
qutenza 24 94.88 High High
TRP channel 158 93.56 High High
imagery 31 90.64 High High
unmyelinated 3 90.36 High High
chronic construction injury 116 88.40 High High
Calcium channel 3 85.96 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 92 99.72 Very High Very High Very High
Nociception 80 99.12 Very High Very High Very High
Injury 270 99.04 Very High Very High Very High
Ganglion Cysts 54 98.40 Very High Very High Very High
Neuropathic Pain 225 95.36 Very High Very High Very High
Targeted Disruption 28 90.56 High High
Overactive Bladder 17 87.20 High High
Attention Deficit Hyperactivity Disorder 3 86.48 High High
Pain 95 63.00 Quite High
Hyperalgesia 43 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected.
Transcription (detected) of TRPA1 associated with qutenza and member 8
1) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344381 Disease Relevance 0.27 Pain Relevance 0.65
TRPA1 was also detected in urothelial cells at both the transcriptional and the protein level.
Transcription (transcriptional) of TRPA1 in urothelial cells
2) Confidence 0.66 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.17 Pain Relevance 0.17
TRPA1 was also detected in urothelial cells at both the transcriptional and the protein level.
Transcription (detected) of TRPA1 in urothelial cells
3) Confidence 0.66 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.17 Pain Relevance 0.16
Distribution of TRPM8 and TRPA1 mRNA after nerve injury
Transcription (Distribution) of TRPA1 mRNA in nerve associated with nervous system injury
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.77 Pain Relevance 0.33
TRPM8 and TRPA1 expression levels after nerve injury
Transcription (levels) of TRPA1 in nerve associated with nervous system injury
5) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.30 Pain Relevance 0.40
However, similar to TRPM8 and TRPA1, this mRNA was also expressed at a lower level after injury (Fig. 2d).
Transcription (expressed) of TRPA1 associated with injury
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.86 Pain Relevance 0.16
We detected a relatively low level of mRNA for TRPM8 and TRPA1 in the DRG of control mice (TRPM8, 106400 copies/µg total RNA, TRPA1, 280900 copies/µg RNA) which correlates well with the selective expression of these channels within small subpopulations of neurons.
Transcription (detected) of TRPA1 in neurons
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.04 Pain Relevance 0.30
The expression of both TRPV1 and TRPA1 transcripts continued to show increases (6 and 4.5-fold, respectively) at 24 and 48 h (Figure 2A and 2C).
Transcription (expression) of TRPA1
8) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.44 Pain Relevance 0.28
Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.
Transcription (levels) of TRPA1
9) Confidence 0.39 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.13
The TRPA1 transcript coding for a channel possibly involved in cold and chemosensation was found in low levels in various brain regions as well as in reproductive organs and spleen (Fig. 2B and 3).
Transcription (found) of TRPA1 in spleen
10) Confidence 0.38 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.10
The TRPA1 transcript coding for a channel possibly involved in cold and chemosensation was found in low levels in various brain regions as well as in reproductive organs and spleen (Fig. 2B and 3).
Transcription (found) of TRPA1 in reproductive organs
11) Confidence 0.13 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.10
These findings were based upon localization of mTRPA1 transcripts and protein in hair cells, deficits in hair cell function after inhibition of TRPA1 protein expression, and similar biophysical and pharmacological properties of heterologously expressed TRPA1 and the hair cell transduction channel.
Transcription (transcripts) of mTRPA1 in hair cells
12) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0

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