INT142502

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.23
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ramp1) signal transduction (Ramp1) transport (Ramp1)
extracellular space (Ramp1) plasma membrane (Ramp1)
Anatomy Link Frequency
neuronal 2
caudate putamen 1
olfactory tubercles 1
cortex 1
nervous system 1
Ramp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 43 98.88 Very High Very High Very High
Migraine 11 94.68 High High
trigeminal ganglion 12 91.92 High High
Trigeminal ganglion neurons 4 90.80 High High
antagonist 4 89.44 High High
Neuropeptide 4 89.20 High High
Inflammation 15 84.24 Quite High
gABA 12 36.08 Quite Low
Glutamate 6 34.40 Quite Low
cytokine 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.98 Very High Very High Very High
Cluster Headache 4 98.36 Very High Very High Very High
Headache 11 94.68 High High
Ganglion Cysts 16 91.92 High High
Neurogenic Inflammation 4 85.12 High High
Male Infertility 3 63.44 Quite High
Bordatella Infection 9 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 9 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we provide evidence that the responsiveness of neuronal CGRP receptors is strongly enhanced in vitro and in vivo by expression of human receptor activity-modifying protein-1 (hRAMP1), an obligatory subunit of the CGRP receptor.
Gene_expression (expression) of hRAMP1 in neuronal associated with calcitonin gene-related peptide
1) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.41 Pain Relevance 0.62
To establish whether RAMP1 is limiting in vivo as indicated from the culture studies, a transgenic mouse expressing hRAMP1 in the nervous system was generated.
Gene_expression (expressing) of hRAMP1 in nervous system associated with targeted disruption
2) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.62 Pain Relevance 0.71
In this study, we provide evidence that the responsiveness of neuronal CGRP receptors is strongly enhanced in vitro and in vivo by expression of human receptor activity-modifying protein-1 (hRAMP1), an obligatory subunit of the CGRP receptor.
Gene_expression (expression) of receptor activity-modifying protein-1 in neuronal associated with calcitonin gene-related peptide
3) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.41 Pain Relevance 0.62
Gene transfer using an adenoviral hRAMP1 expression vector increased the maximal production of cAMP by 1.8 +/- 0.2-fold and decreased the EC50 to 2.3 +/- 0.8 nM from 9.0 +/- 5.9 nM and 15.6 +/- 5.2 nM in uninfected and control-infected cultures, respectively.
Gene_expression (expression) of hRAMP1
4) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.60 Pain Relevance 0.61
Calcitonin receptor-like receptor has been shown to be co-expressed with RAMP1 in cortex, caudate putamen and olfactory tubercles, providing selective specificity to calcitonin gene-related peptide (CGRP) and regulation of endothelial cell proliferation [73].
Gene_expression (expressed) of RAMP1 in caudate putamen associated with calcitonin gene-related peptide
5) Confidence 0.13 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.06 Pain Relevance 0.05
Calcitonin receptor-like receptor has been shown to be co-expressed with RAMP1 in cortex, caudate putamen and olfactory tubercles, providing selective specificity to calcitonin gene-related peptide (CGRP) and regulation of endothelial cell proliferation [73].
Gene_expression (expressed) of RAMP1 in olfactory tubercles associated with calcitonin gene-related peptide
6) Confidence 0.05 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.06 Pain Relevance 0.05
Calcitonin receptor-like receptor has been shown to be co-expressed with RAMP1 in cortex, caudate putamen and olfactory tubercles, providing selective specificity to calcitonin gene-related peptide (CGRP) and regulation of endothelial cell proliferation [73].
Gene_expression (expressed) of RAMP1 in cortex associated with calcitonin gene-related peptide
7) Confidence 0.05 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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