INT142503

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ramp1) signal transduction (Ramp1) transport (Ramp1)
extracellular space (Ramp1) plasma membrane (Ramp1)
Anatomy Link Frequency
neuronal 4
Ramp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 99.54 Very High Very High Very High
Migraine 4 96.00 Very High Very High Very High
trigeminal ganglion 6 93.24 High High
Trigeminal ganglion neurons 2 90.80 High High
Neuropeptide 2 90.52 High High
antagonist 2 78.72 Quite High
Inflammation 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Headache 4 96.00 Very High Very High Very High
Ganglion Cysts 8 93.24 High High
Cluster Headache 2 61.04 Quite High
Targeted Disruption 4 31.68 Quite Low
Neurogenic Inflammation 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we provide evidence that the responsiveness of neuronal CGRP receptors is strongly enhanced in vitro and in vivo by expression of human receptor activity-modifying protein-1 (hRAMP1), an obligatory subunit of the CGRP receptor.
Positive_regulation (enhanced) of Gene_expression (expression) of hRAMP1 in neuronal associated with calcitonin gene-related peptide
1) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.42 Pain Relevance 0.63
In this study, we provide evidence that the responsiveness of neuronal CGRP receptors is strongly enhanced in vitro and in vivo by expression of human receptor activity-modifying protein-1 (hRAMP1), an obligatory subunit of the CGRP receptor.
Positive_regulation (enhanced) of Gene_expression (expression) of receptor activity-modifying protein-1 in neuronal associated with calcitonin gene-related peptide
2) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.41 Pain Relevance 0.63

General Comments

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