INT142525

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.94
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
sciatic nerve 1
astrocyte 1
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 65 100.00 Very High Very High Very High
Sciatic nerve 18 100.00 Very High Very High Very High
Morphine 17 99.42 Very High Very High Very High
Antinociceptive 5 97.72 Very High Very High Very High
Spinal cord 10 96.76 Very High Very High Very High
Endep 7 96.74 Very High Very High Very High
spinal dorsal horn 24 96.24 Very High Very High Very High
Dorsal horn 6 92.64 High High
excitatory amino acid 4 88.40 High High
cerebral cortex 2 88.00 High High
Disease Link Frequency Relevance Heat
Thyroid Disease 4 99.92 Very High Very High Very High
Nervous System Injury 26 89.16 High High
Injury 6 81.80 Quite High
Cretinism 4 75.00 Quite High
Intellectual Impairment 2 66.92 Quite High
Hypersensitivity 8 20.76 Low Low
Nociception 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the total amount of GLT-1 and GLAST one day after ligation did not change.
GLT-1 Binding (ligation) of
1) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.23 Pain Relevance 0.14
The results of this study demonstrate plasticity not only in the expression levels but also in the cellular localization of the glutamate transporters GLT-1 and GLAST following partial sciatic nerve ligation.
GLT-1 Spec (partial) Binding (ligation) of in sciatic nerve associated with glutamate and sciatic nerve
2) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.12 Pain Relevance 0.25
Acute amitriptyline treatment potentiated morphine's antinociceptive effect, with a 5.3-fold leftward shift of morphine's dose-response curve in morphine-tolerant rats, and this was associated with GLAST and GLT-1 trafficking onto the cell surface.
GLT-1 Binding (associated) of associated with antinociceptive, endep and morphine
3) Confidence 0.23 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.82
Moreover, we verified the immunocontent of astrocyte glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) as well as activation of mitogen-activated protein kinases (MAPKs) in hypothyroid rats.
GLT-1 Binding (immunocontent) of in astrocyte associated with glutamate
4) Confidence 0.11 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.18
Results showed that hypothyroidism is associated with decreased GLAST and GLT-1 immunocontent.
GLT-1 Binding (associated) of associated with thyroid disease
5) Confidence 0.11 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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