INT142526

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.48
Pain Relevance 8.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 4
spinal cord dorsal horn 4
SON 3
hippocampus 3
brain 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 72 100.00 Very High Very High Very High
nav1.8 65 100.00 Very High Very High Very High
Kinase C 58 100.00 Very High Very High Very High
Dorsal column 124 99.84 Very High Very High Very High
Morphine 36 99.80 Very High Very High Very High
Endep 14 99.70 Very High Very High Very High
Spinal cord 52 99.68 Very High Very High Very High
Dorsal horn 15 99.28 Very High Very High Very High
antagonist 19 95.44 Very High Very High Very High
Pain 29 94.56 High High
Disease Link Frequency Relevance Heat
Convulsion 63 99.86 Very High Very High Very High
Nociception 74 95.16 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

54 94.52 High High
INFLAMMATION 23 93.60 High High
Death 12 90.60 High High
Apoptosis 25 90.00 High High
Epilepsy 19 83.92 Quite High
Pain 25 79.96 Quite High
Ganglion Cysts 45 74.40 Quite High
Status Epilepticus 1 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Repeated EA has a cumulative analgesic effect in CCI rats, which is probably related to its resultant upregulation of PKA expression in neurons of hypothalamus and hippocampus and the animals' neuro-memory.


Positive_regulation (upregulation) of Gene_expression (expression) of PKA in hippocampus
1) Confidence 0.46 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
IGV of PVN and SON in OVX + CCI + EA 2 w group were also markedly lower than those in OVX + CCI group (P<0.05), displaying upregulation and cumulative increase of PKA expression by EA 2 w.
Positive_regulation (increase) of Gene_expression (expression) of PKA in SON
2) Confidence 0.46 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Positive_regulation (triggers) of Gene_expression (expression) of PKA in brain associated with convulsion
3) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.72 Pain Relevance 0.03
Furthermore, long-term morphine infusion up-regulated PKA and PKC protein expression in the spinal cord dorsal horn, while amitriptyline inhibited the increase in expression of phospho-PKA, PKCalpha, PKCbetaII, and PKCgamma.
Positive_regulation (up-regulated) of Gene_expression (expression) of PKA in spinal cord dorsal horn associated with dorsal horn, endep, spinal cord and morphine
4) Confidence 0.25 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 2.24
In addition, during the persistent hypernociceptive state, the PKA and PKCvarepsilon expression and activity in the DRG are up-regulated and the administration of the PKA and PKCvarepsilon inhibitors reduce the hypernociception as well as the Na(V)1.8 mRNA level.
Positive_regulation (up-regulated) of Gene_expression (expression) of PKA in DRG
5) Confidence 0.20 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.58 Pain Relevance 0.34
Furthermore, long-term morphine infusion up-regulated PKA and PKC protein expression in the spinal cord dorsal horn, while amitriptyline inhibited the increase in expression of phospho-PKA, PKCalpha, PKCbetaII, and PKCgamma.
Positive_regulation (increase) of Gene_expression (expression) of phospho-PKA in spinal cord dorsal horn associated with dorsal horn, endep, spinal cord and morphine
6) Confidence 0.18 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 2.23
To combine the finding of the increased expression of PKA in PSDC neurons, we could suggest that a possible role for PKA in regulation of AMPA receptor activity in PSDC neurons during visceral painful states.
Positive_regulation (increased) of Gene_expression (expression) of PKA in neurons associated with pain and dorsal column
7) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.13 Pain Relevance 0.94
IGV of PVN and SON in OVX + CCI + EA 2 w group were also markedly lower than those in OVX + CCI group (P<0.05), displaying upregulation and cumulative increase of PKA expression by EA 2 w.
Positive_regulation (increase) of in PVN Gene_expression (expression) of PKA in SON
8) Confidence 0.16 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Repeated EA has a cumulative analgesic effect in CCI rats, which is probably related to its resultant upregulation of PKA expression in neurons of hypothalamus and hippocampus and the animals' neuro-memory.


Positive_regulation (upregulation) of in hypothalamus Gene_expression (expression) of PKA in hippocampus
9) Confidence 0.16 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
We found that intracolonic injection of mustard oil significantly induced the expression of PKA kinase protein, as well as CREB, in the lumbosacral spinal cord and in pre-labeled PSDC neurons.
Positive_regulation (induced) of Gene_expression (expression) of PKA in neurons associated with dorsal column and spinal cord
10) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.64 Pain Relevance 0.81
Involvement of cAMP and PKA activity in mediating the effect of NAR
Positive_regulation (mediating) of Gene_expression (activity) of PKA
11) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0 Pain Relevance 0
Sar-SP-induced potentiation of Nav1.8 via PKC, but not PKA
Positive_regulation (potentiation) of Gene_expression (Sar) of PKA associated with kinase c, nav1.8 and substance p
12) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.18 Pain Relevance 1.46

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