INT142529

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.65
Pain Relevance 6.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord dorsal horn 2
glial cell 1
GTS (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 15 100.00 Very High Very High Very High
Spinal cord 6 99.64 Very High Very High Very High
tolerance 5 99.54 Very High Very High Very High
excitatory amino acid 10 99.48 Very High Very High Very High
Dorsal horn 4 99.16 Very High Very High Very High
Morphine 47 99.12 Very High Very High Very High
Inflammation 1 99.02 Very High Very High Very High
Antinociceptive 20 98.84 Very High Very High Very High
narcan 14 98.66 Very High Very High Very High
intrathecal 5 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 99.02 Very High Very High Very High
Bordatella Infection 6 90.48 High High
Hyperalgesia 2 90.00 High High
Neuropathic Pain 1 36.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of glutamate transporters (GTs) in the spinal cord dorsal horn was also measured.
Gene_expression (expression) of GTs in spinal cord dorsal horn associated with glutamate, dorsal horn and spinal cord
1) Confidence 0.29 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680732 Disease Relevance 0.17 Pain Relevance 0.94
In addition, concentrations of glutamate and aspartate were higher in baseline-P dialysates than in baseline-B dialysates, and the expression of the GTs (GLT-1, GLAST, and EAAC1) was downregulated by PTX treatment.
Gene_expression (expression) of GTs associated with glutamate
2) Confidence 0.29 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680732 Disease Relevance 0.13 Pain Relevance 1.30
Intrathecal co-infusion of ultra-low dose naloxone (15pg/h) with morphine attenuated tolerance development, reversed GTs expression, inhibited the NMDAR NR1 subunit expression and phosphorylation, and PKCgamma expression, inhibited glial cell activation, and suppressed the morphine-evoked EAAs release.
Gene_expression (expression) of GTs in glial cell associated with tolerance, narcan, excitatory amino acid, morphine and intrathecal
3) Confidence 0.09 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20478329 Disease Relevance 0 Pain Relevance 1.83
Long-term morphine infusion induced antinociceptive tolerance and down-regulation of glutamate transporters (GTs), GLAST, GLT-1, and EAAC1, expression in the rat spinal cord dorsal horn.
Gene_expression (expression) of GTs in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, spinal cord and morphine
4) Confidence 0.05 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.62
In the present study, we examined the underlying mechanisms of this anti-inflammatory effect in PTX-treated rats, particularly on the expression of GTs.
Gene_expression (expression) of GTs associated with inflammation
5) Confidence 0.05 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409222 Disease Relevance 0.35 Pain Relevance 0.80

General Comments

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