INT14254

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Context Info
Confidence 0.50
First Reported 1990
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
plasma 2
tail 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 9 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 96.64 Very High Very High Very High
Spinal cord 2 75.60 Quite High
Neuropeptide 3 75.00 Quite High
Dynorphin 3 75.00 Quite High
neuropeptide release 3 74.84 Quite High
antinociception 1 70.60 Quite High
Antinociceptive 2 66.08 Quite High
narcan 2 65.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposing the animal's tail to the noxious cold (30 sec/min for 20 min) resulted in a significant elevation in SP release (69% above base-line levels), but no change in the level of SST release.
Positive_regulation (elevation) of Neg (no) Regulation (change) of SST in tail associated with somatostatin and substance p
1) Confidence 0.50 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1690293 Disease Relevance 0 Pain Relevance 0.97
We conclude that cisplatin neuropathy is accompanied by an increase in plasma somatostatin immunoreactivity with an increase in SSTR4 expression in rats.
Positive_regulation (increase) of Regulation (immunoreactivity) of somatostatin in plasma associated with neuropathic pain and somatostatin
2) Confidence 0.24 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.23 Pain Relevance 0.56

General Comments

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