INT142568

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.25
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 26 99.98 Very High Very High Very High
Kinase C 117 98.84 Very High Very High Very High
opioid receptor 252 98.36 Very High Very High Very High
Analgesic 57 97.20 Very High Very High Very High
Morphine 231 96.40 Very High Very High Very High
tolerance 84 92.88 High High
nMDA receptor antagonist 1 91.64 High High
Periaqueductal grey 54 85.08 High High
Spinal cord 10 83.28 Quite High
nMDA receptor 4 78.48 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 54 85.08 High High
Neuropathic Pain 1 64.64 Quite High
Apoptosis 3 38.08 Quite Low
Death 3 26.56 Quite Low
Nociception 21 5.00 Very Low Very Low Very Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Intractable Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N/OFQ receptor antagonists attenuated the nNOS activity stimulated by N/OFQ, but not that by NMDA.
Negative_regulation (attenuated) of Neg (not) Positive_regulation (stimulated) of nNOS associated with antagonist
1) Confidence 0.37 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17350656 Disease Relevance 0.06 Pain Relevance 0.61
Notably, early Akt-nNOS activation was immediately followed by a decrease in its strength prior to the 30 min interval, the time when the peak analgesic effect of morphine was reached.
Negative_regulation (decrease) of Positive_regulation (activation) of nNOS associated with analgesic and morphine
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.09 Pain Relevance 0.94
The activation of the Akt-nNOS pathway was also reduced by the binding of these proteins to the MOR-HINT1 complex where they remained inactive.
Negative_regulation (reduced) of Positive_regulation (activation) of nNOS associated with opioid receptor
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.09
During intervals of diminished NO production due to the loss of Akt activity and the action of CaMKII on nNOS, the zinc ions required for PKC?
Neg (NO) Negative_regulation (diminished) of Positive_regulation (action) of nNOS associated with kinase c
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.66

General Comments

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