INT142572

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
D5Pas1 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
nMDA receptor antagonist 1 100.00 Very High Very High Very High
Spinal cord 10 93.88 High High
nMDA receptor 3 78.64 Quite High
Neuronal nitric oxide synthase 2 77.04 Quite High
Neuropathic pain 2 75.24 Quite High
orphanin 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 75.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the NOR3-enhanced nNOS activity was completely inhibited by NMDA antagonists MK-801 and d-AP5, partially by the GluRepsilon2-selective antagonist CP-101,606, and was attenuated in GluRepsilon1(-/-) and GluRepsilon1(-/-)/epsilon4(-/-) mice.
and d-AP5 Negative_regulation (inhibited) of nNOS associated with antagonist
1) Confidence 0.02 Published 2007 Journal Nitric Oxide Section Abstract Doc Link 17548218 Disease Relevance 0.07 Pain Relevance 0.47
The N/OFQ-stimulated nNOS activity was inhibited by NMDA receptor antagonists MK-801 and D-AP5, but not by the NR2B-selective antagonist CP-101,606; and the stimulated activity was observed in NR2D(-/-) mice, but not in NR2A(-/-) or NR2A(-/-)/NR2D(-/-) mice.
D-AP5 Negative_regulation (inhibited) of nNOS associated with nmda receptor antagonist and antagonist
2) Confidence 0.01 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17350656 Disease Relevance 0.08 Pain Relevance 0.64

General Comments

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