INT14258

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Context Info
Confidence 0.60
First Reported 1981
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 10.16
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TSPO) mitochondrion (TSPO) aging (TSPO)
response to stress (TSPO)
Anatomy Link Frequency
brain 2
T cells 2
lymph nodes 1
spleen 1
intestine 1
TSPO (Homo sapiens)
Pain Link Frequency Relevance Heat
anakinra 42 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
Versed 5 100.00 Very High Very High Very High
cINOD 1 100.00 Very High Very High Very High
agonist 3 99.96 Very High Very High Very High
antagonist 55 99.08 Very High Very High Very High
Dismenorea 11 98.96 Very High Very High Very High
Pain 45 98.32 Very High Very High Very High
adenocard 8 98.10 Very High Very High Very High
Neurotransmitter 2 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 9 100.00 Very High Very High Very High
Immunotherapy Of Cancer 1 99.32 Very High Very High Very High
Reprotox - General 1 11 98.96 Very High Very High Very High
Nociception 20 98.92 Very High Very High Very High
Multiple Sclerosis 264 98.56 Very High Very High Very High
Pain 44 98.32 Very High Very High Very High
Death 37 97.52 Very High Very High Very High
Sleep Disorders 7 96.48 Very High Very High Very High
Overactive Bladder 8 95.60 Very High Very High Very High
Infection 349 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peripheral benzodiazepine receptor (PBR) both regulates the formation of neurosteroids and is, in animals, regulated by ovarian steroids.
Regulation (regulated) of PBR
1) Confidence 0.60 Published 2001 Journal Psychoneuroendocrinology Section Abstract Doc Link 11403976 Disease Relevance 0.10 Pain Relevance 0.15
The immobilization of the NSAID ibuprofen (Hibp) and the Cu(II)-ibp compound on magnesium-aluminum layered double hydroxides (Mg3Al-LDH) is described.
Regulation (immobilization) of ibp associated with cinod
2) Confidence 0.44 Published 2005 Journal J Pharm Sci Section Abstract Doc Link 15793807 Disease Relevance 0 Pain Relevance 0.10
Effects of the benzodiazepine receptor agonist midazolam and antagonist flumazenil on 5-hydroxytryptamine release from guinea-pig intestine in vitro.
Regulation (Effects) of benzodiazepine receptor in intestine associated with versed, antagonist and agonist
3) Confidence 0.40 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 1690357 Disease Relevance 0 Pain Relevance 0.52
Neither post-operative sequelae nor cancer treatment including radiotherapy seemed to affect the occurrence of PBS.
Regulation (affect) of PBS associated with syndrome and immunotherapy of cancer
4) Confidence 0.23 Published 1989 Journal Pain Section Abstract Doc Link 2785259 Disease Relevance 1.66 Pain Relevance 0.91
Since inclusion on the PBS in December 2004, anakinra had accounted for 115 prescriptions (A$164,000) under the PBS and 5 prescriptions (A$7,100) under the RPBS (Table 2).


Regulation (accounted) of PBS associated with anakinra
5) Confidence 0.21 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1828161 Disease Relevance 0.12 Pain Relevance 0.47
Since inclusion on the PBS in December 2004, anakinra had accounted for 115 prescriptions (A$164,000) under the PBS and 5 prescriptions (A$7,100) under the RPBS (Table 2).


Regulation (accounted) of PBS associated with anakinra
6) Confidence 0.21 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1828161 Disease Relevance 0.12 Pain Relevance 0.47
Skills are certainly not directly interchangeable between these two IBP types.
Neg (not) Regulation (interchangeable) of IBP
7) Confidence 0.18 Published 2010 Journal World J Surg Section Body Doc Link PMC2848730 Disease Relevance 0 Pain Relevance 0
We examine here the possibility that the mechanism may involve modulation of the cerebral benzodiazepine receptor.
Regulation (modulation) of benzodiazepine receptor
8) Confidence 0.18 Published 1981 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6108979 Disease Relevance 0.09 Pain Relevance 0.37
Controlling government expenditure on the PBS while maintaining social equity and access to 'essential medicines' is at the centre of an ongoing public debate.
Regulation (Controlling) of PBS
9) Confidence 0.13 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1828161 Disease Relevance 0 Pain Relevance 0
The mechanism by which adenosine increases sleep at this site is not clear, but one possibility is that this is related to its effects on the GABA(A)-benzodiazepine receptor complex.
Regulation (effects) of benzodiazepine receptor associated with gaba and adenocard
10) Confidence 0.05 Published 2000 Journal Brain Res. Section Abstract Doc Link 10678777 Disease Relevance 0.16 Pain Relevance 0.33
From these findings, a high correlation could be determined between IBP change and variation in the DC component of PPG (Fig. 5, Table 1).


Spec (determined) Regulation (change) of IBP
11) Confidence 0.03 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2852789 Disease Relevance 0 Pain Relevance 0.03
There is evidence supporting a role of melatonin in the regulation of the GABA-benzodiazepine receptor complex, and it appears that melatonin potentiates this inhibitory neurotransmitter system in brain.
Regulation (regulation) of GABA-benzodiazepine receptor in brain associated with neurotransmitter and gaba
12) Confidence 0.03 Published 1995 Journal J. Pineal Res. Section Abstract Doc Link 8609597 Disease Relevance 0.16 Pain Relevance 0.43
In the Fig. 2 the cell control and PBS control shows the maximum counts of [3H]thymidine (around 36000 cpm/mg protein) when compared to the treatment groups.
Regulation (control) of PBS
13) Confidence 0.03 Published 2006 Journal J Carcinog Section Body Doc Link PMC1705806 Disease Relevance 0.05 Pain Relevance 0
Prolyl hydroxylase activities were 103, 289, and 193% of SA + PBS control in SA + DC, BL + PBS, and BL + DC groups, respectively.
Regulation (control) of PBS
14) Confidence 0.02 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9416971 Disease Relevance 0.20 Pain Relevance 0.17
Data are expressed as the percentage change over the PBS control.


Regulation (control) of PBS
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.14 Pain Relevance 0.03
Susceptibility rose to a peak at about 3 hours, then declined to the baseline susceptibility of PBS controls at 6 hours.
Regulation (controls) of PBS
16) Confidence 0.01 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.15 Pain Relevance 0.03
The changes at each time point in the number of cell layers, cellular debris in the lumen, and number of macrophages in the lumen, were compared with those for PBS controls using the unpaired t-test for 2-tailed P value.
Regulation (controls) of PBS in lumen
17) Confidence 0.01 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.15 Pain Relevance 0.05
In each of the 18 animals, BMP-7 was injected into the right knee and PBS into the left, as a control.


Regulation (control) of PBS in knee
18) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592805 Disease Relevance 0.20 Pain Relevance 0
Figure 10 demonstrates that rtnPTX3 bound to human C1q compared to either the BSA or PBS control (Fig. 10).


Regulation (control) of PBS
19) Confidence 0.01 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2430192 Disease Relevance 0.24 Pain Relevance 0
The cells were infected with Ad5CMV-p53 (5×108 vp), Ad5CMV (5×108 vp) or PBS as a control at days 1, 2, 3, 4, and 5 of incubation at 37?.
Regulation (control) of PBS
20) Confidence 0.01 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.24 Pain Relevance 0

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