INT142594

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 165
Total Number 170
Disease Relevance 139.73
Pain Relevance 22.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
macrophages 7
kidney 5
monocytes 5
epithelial cells 5
brain 4
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2543 100.00 Very High Very High Very High
cytokine 1652 100.00 Very High Very High Very High
agonist 242 100.00 Very High Very High Very High
rheumatoid arthritis 430 99.98 Very High Very High Very High
Hippocampus 55 99.80 Very High Very High Very High
Morphine 67 99.60 Very High Very High Very High
fibrosis 919 99.44 Very High Very High Very High
Spinal cord 17 99.12 Very High Very High Very High
Central nervous system 309 98.80 Very High Very High Very High
Pyramidal cell 24 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3097 100.00 Very High Very High Very High
Hydronephrosis 2002 100.00 Very High Very High Very High
Infection 1872 100.00 Very High Very High Very High
Rheumatoid Arthritis 431 99.98 Very High Very High Very High
Acne 164 99.98 Very High Very High Very High
Ureteral Obstruction 936 99.84 Very High Very High Very High
Mycobacterial Infection 489 99.80 Very High Very High Very High
Cancer 2739 99.70 Very High Very High Very High
Hemophilus Infection 712 99.70 Very High Very High Very High
Internal Fibrosis 234 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apical expression of TLR2 on tubular cells could be optimal for interaction with filtered or leaked stress ligands [30]–[32] or with ligands that are expressed apically [33].
Gene_expression (expression) of TLR2 associated with stress and hydronephrosis
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 2.48 Pain Relevance 0.14
Of particular interest was the observation that several renal myofibroblasts coexpressed TLR2.
Gene_expression (coexpressed) of TLR2 associated with hydronephrosis
2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.77 Pain Relevance 0.05
This would agree with our observations that various renal myofibroblasts and in particular macrophages express TLR2.
Gene_expression (express) of TLR2 in macrophages associated with hydronephrosis
3) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.82 Pain Relevance 0.34
In addition, behavioral studies using toll-like receptor 2 knock-out mice demonstrate that the expression of toll-like receptor 2 is required for the induction of mechanical allodynia and thermal hyperalgesia due to spinal nerve axotomy.
Gene_expression (expression) of toll-like receptor 2 in spinal nerve associated with targeted disruption, allodynia and thermal hyperalgesia
4) Confidence 0.77 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17355971 Disease Relevance 1.42 Pain Relevance 0.80
TLR2 expression on the dendritic cells was also needed for an effective anti-tumor immune response and for tumor regression.
Gene_expression (expression) of TLR2 in dendritic cells associated with cancer
5) Confidence 0.76 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.27 Pain Relevance 0
The researchers show that their strategy increased the migration of dendritic cells into the tumor provided they expressed an immune system protein called Toll-like receptor 2 (TLR2).
Gene_expression (expressed) of Toll-like receptor 2 in immune system associated with cancer
6) Confidence 0.76 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.28 Pain Relevance 0
The researchers show that their strategy increased the migration of dendritic cells into the tumor provided they expressed an immune system protein called Toll-like receptor 2 (TLR2).
Gene_expression (expressed) of TLR2 in immune system associated with cancer
7) Confidence 0.76 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.28 Pain Relevance 0
TLR2 expression on bone marrow-derived DCs (BMDC) was necessary to stimulate a systemic antiglioma immune response.
Gene_expression (expression) of TLR2 in bone marrow
8) Confidence 0.76 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.18 Pain Relevance 0.13
Importantly, TLR2 was expressed on several human tumor cell lines (Methods S1).
Gene_expression (expressed) of TLR2 associated with cancer
9) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.18 Pain Relevance 0.13
The pSilencer 1.0 U6 vector, expressing small hairpin RNA (shRNA) against TLR2, TLR6 or Dectin-1, was constructed.
Gene_expression (expressing) of TLR2
10) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0 Pain Relevance 0
Activation of TLR2 by LPS significantly enhanced the expression of TLR2 on these cells (Figure S1E).
Gene_expression (expression) of TLR2
11) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.19 Pain Relevance 0.19
Firstly, the highly metastatic B16 cells not only release higher level of HSP60, but also have a higher-level expression of TLR2 and basal activity of Stat3 compared to low metastatic B16-F1 cells.
Gene_expression (expression) of TLR2 in B16-F1
12) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.74 Pain Relevance 0.05
Our studies demonstrate that the activation TLR2 expressed on B16 cells not only determines the invasiveness of these cells, but also facilitates tumor metastasis due to promoting the formation of the immunosuppressive microenvironment.
Gene_expression (expressed) of TLR2 associated with metastasis
13) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.51 Pain Relevance 0.21
In agreement, we found that patients with severe IgA nephropathy had a predominant interstitial TLR2 expression with occasionally apical staining of tubuli.
Gene_expression (expression) of TLR2 associated with hydronephrosis and renal disease
14) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 2.62 Pain Relevance 0.20
No effect of TLR2 deficiency on UUO-induced tubular injury and ECM accumulation
Gene_expression (deficiency) of TLR2 associated with ureteral obstruction and injury
15) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.78 Pain Relevance 0.04
In this context, it has recently been shown that TLR2 can sense pancreatic ?
Gene_expression (sense) of TLR2
16) Confidence 0.66 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.75 Pain Relevance 0.29
This suggests that circulating monocytes may be a major cellular source of TLR2 expression in patients with AMI.
Gene_expression (expression) of TLR2 in monocytes
17) Confidence 0.65 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.50 Pain Relevance 0.16
Levels of TLR2 and TLR4
Gene_expression (Levels) of TLR2
18) Confidence 0.65 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.25 Pain Relevance 0
Systemic levels of TLR2 and TLR4 were higher in patients with AMI than in patients with SA and controls.
Gene_expression (levels) of TLR2
19) Confidence 0.65 Published 2008 Journal Clinical Science (London, England : 1979) Section Abstract Doc Link PMC2552974 Disease Relevance 0.35 Pain Relevance 0.16
The aim of the present study was to determine whether TLR2 and TLR4 are expressed at the site of ruptured plaques in patients with AMI and to compare this with systemic levels.
Gene_expression (expressed) of TLR2 in plaques
20) Confidence 0.65 Published 2008 Journal Clinical Science (London, England : 1979) Section Abstract Doc Link PMC2552974 Disease Relevance 0.43 Pain Relevance 0.17

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