INT142595

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 19.17
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
macrophage 2
cardiac myocytes 1
spinal cord 1
nucleus 1
microglia 1
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 19 99.82 Very High Very High Very High
chemokine 69 99.24 Very High Very High Very High
Inflammation 322 99.12 Very High Very High Very High
cytokine 301 98.92 Very High Very High Very High
Inflammatory response 81 97.48 Very High Very High Very High
Thermal hyperalgesia 3 95.80 Very High Very High Very High
metalloproteinase 70 95.56 Very High Very High Very High
allodynia 3 94.80 High High
tolerance 56 94.40 High High
depression 1 94.24 High High
Disease Link Frequency Relevance Heat
Hydronephrosis 308 100.00 Very High Very High Very High
Targeted Disruption 40 99.96 Very High Very High Very High
Stress 37 99.60 Very High Very High Very High
INFLAMMATION 406 99.12 Very High Very High Very High
Apoptosis 206 98.96 Very High Very High Very High
Metastasis 138 98.84 Very High Very High Very High
Nervous System Injury 15 98.82 Very High Very High Very High
Ureteral Obstruction 144 98.44 Very High Very High Very High
Cancer 257 98.20 Very High Very High Very High
Infection 154 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, treatment with rhBCL2A1 protein did not protect mice deficient in toll-like receptor-2 (TLR2) or the adaptor protein, myeloid differentiation factor-88 (MyD88).


Negative_regulation (deficient) of TLR2
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816997 Disease Relevance 0.71 Pain Relevance 0.15
Notably, treatment with rhBCL2A1 protein did not protect mice deficient in toll-like receptor-2 (TLR2) or the adaptor protein, myeloid differentiation factor-88 (MyD88).


Negative_regulation (deficient) of toll-like receptor-2
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816997 Disease Relevance 0.71 Pain Relevance 0.15
in mice lacking TLR2 could be that there is a reduction in TLR2-dependent macrophage and (myo)fibroblast activation.
Negative_regulation (reduction) of TLR2 in macrophage associated with hydronephrosis
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.99 Pain Relevance 0.38
TLR2 deficiency significantly inhibited the metastasis and progression of melanoma, as well as nucleus division stage (Fig. 6A–D), leading to a significant reduction in the animal deaths.
Negative_regulation (deficiency) of TLR2 in nucleus associated with skin cancer and metastasis
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.98 Pain Relevance 0.07
Moreover, targeting TLR2 inhibits the expression of chemokines CCL22, MCP-1 and CCR8 to attenuate the recruitment of suppressive immune cells to the tumor microenvironment [26], [35] and result in an overall reduction of suppressive cytokines in the tumor tissue.
Negative_regulation (inhibits) of TLR2 in immune cells associated with chemokine, cancer and cytokine
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.31 Pain Relevance 0.10
Loss of apical TLR2 staining in tubuli in later phases of UUO or during severe forms of IgA nephropathy could reflect loss of apical brush border due to tubular damage.
Negative_regulation (Loss) of TLR2 in brush associated with hydronephrosis, ureteral obstruction and renal disease
6) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.74 Pain Relevance 0.06
Surprisingly, MMP2/TIMP2 and MMP9/TIMP1 mRNA expression and MMP9 activity was considerably reduced in TLR2?
Negative_regulation (reduced) of TLR2 associated with hydronephrosis
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.36 Pain Relevance 0.33
in mice lacking TLR2 could be that there is a reduction in TLR2-dependent macrophage and (myo)fibroblast activation.
Negative_regulation (reduction) of TLR2 in macrophage associated with hydronephrosis
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.98 Pain Relevance 0.37
The nerve injury-induced spinal cord microglia and astrocyte activation is reduced in the toll-like receptor 2 knock-out mice.
Negative_regulation (reduced) of toll-like receptor 2 in astrocyte associated with targeted disruption, nervous system injury and spinal cord
9) Confidence 0.37 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17355971 Disease Relevance 1.43 Pain Relevance 0.81
Similarly, the nerve injury-induced pro-inflammatory gene expression in the spinal cord is also reduced in the toll-like receptor 2 knock-out mice.
Negative_regulation (reduced) of toll-like receptor 2 in spinal cord associated with targeted disruption, nervous system injury, inflammation and spinal cord
10) Confidence 0.37 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17355971 Disease Relevance 1.38 Pain Relevance 0.80
TLR2 has anti-apoptotic effect in stressed or injured cardiac myocytes, as inhibition of TLR2 enhances stress-induced cytotoxicity [66].
Negative_regulation (inhibition) of TLR2 in cardiac myocytes associated with stress and apoptosis
11) Confidence 0.37 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 1.05 Pain Relevance 0.11
The ratio between the copy numbers of TLR2, TLR4 and GAPDH represented the normalized TLR2 and TLR4 levels for each sample and could be compared with those of other samples.
Negative_regulation (numbers) of TLR2
12) Confidence 0.36 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0 Pain Relevance 0
Shigeoka et al. observed similar results showing that TLR2 deficiency provided more protection than a deficiency in MyD88 or TRIF individually or a combination of those two adapter molecules [27].
Negative_regulation (deficiency) of TLR2
13) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.33 Pain Relevance 0
Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor

Background

Negative_regulation (Blocking) of TLR2 associated with cancer and metastasis
14) Confidence 0.35 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2716531 Disease Relevance 1.17 Pain Relevance 0.11
The published sequences for human TLR2 (forward primer, 5?
Negative_regulation (published) of TLR2
15) Confidence 0.31 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0 Pain Relevance 0
Mal-deficient mice show a reduction in TLR4- and TLR2-induced NF-?
Negative_regulation (reduction) of TLR2
16) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.51 Pain Relevance 0.13
Herein, this paradigm is challenged by demonstrating that recognition of live Borrelia burgdorferi not only triggers an inflammatory response in the absence of CD14, but one that is, in part, a consequence of altered PI3K/AKT/p38-MAPK signaling and impaired negative regulation of TLR2.
Negative_regulation (regulation) of TLR2 associated with lyme disease and inflammatory response
17) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.43 Pain Relevance 0.28
TLR2 deficiency had the opposite effect insofar as release of TNF-?
Negative_regulation (deficiency) of TLR2
18) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.06 Pain Relevance 0.12
For example, the TLR2-mediated response to phenol-soluble modulin is enhanced by TLR6 but inhibited by TLR1, indicating functional interactions between these receptors [23].

3.

Negative_regulation (inhibited) of TLR2
19) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0 Pain Relevance 0.12
Those authors found that the effect of PGN was critically dependent on TLR2, as TLR2-deficient mice demonstrated reduced cytokine and chemokine production after PGN challenge [34].
Negative_regulation (dependent) of TLR2 associated with chemokine and cytokine
20) Confidence 0.25 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.31 Pain Relevance 0.40

General Comments

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