INT142596

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 38.41
Pain Relevance 6.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
lung 8
macrophages 4
epithelial cells 4
neutrophils 4
spinal nerve 2
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 437 100.00 Very High Very High Very High
Hippocampus 12 99.98 Very High Very High Very High
rheumatoid arthritis 206 99.96 Very High Very High Very High
allodynia 1 98.68 Very High Very High Very High
tolerance 41 98.44 Very High Very High Very High
Morphine 7 98.36 Very High Very High Very High
Inflammation 802 98.20 Very High Very High Very High
Thermal hyperalgesia 1 98.12 Very High Very High Very High
fibrosis 116 95.68 Very High Very High Very High
ischemia 77 93.96 High High
Disease Link Frequency Relevance Heat
Infection 543 100.00 Very High Very High Very High
Hydronephrosis 231 100.00 Very High Very High Very High
Sepsis 74 100.00 Very High Very High Very High
Hemophilus Infection 534 99.98 Very High Very High Very High
Rheumatoid Arthritis 206 99.96 Very High Very High Very High
Mycobacterial Infection 150 99.84 Very High Very High Very High
Apoptosis 243 99.66 Very High Very High Very High
Targeted Disruption 134 99.60 Very High Very High Very High
Disease 405 99.44 Very High Very High Very High
Renal Disease 110 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, behavioral studies using toll-like receptor 2 knock-out mice demonstrate that the expression of toll-like receptor 2 is required for the induction of mechanical allodynia and thermal hyperalgesia due to spinal nerve axotomy.
Positive_regulation (required) of Gene_expression (expression) of toll-like receptor 2 in spinal nerve associated with targeted disruption, allodynia and thermal hyperalgesia
1) Confidence 0.69 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17355971 Disease Relevance 1.42 Pain Relevance 0.80
Similar to patients with hydronephrosis we found a strong increase of TLR2 expression in all the fifteen analyzed kidneys of IgA nephropathy patients (Fig. 1C and D) compared to control renal biopsy specimens (Fig. 1A).
Positive_regulation (increase) of Gene_expression (expression) of TLR2 associated with hydronephrosis and renal disease
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.19 Pain Relevance 0.18
Recently, it was shown that Toll-like receptor 2 (TLR2) is expressed in the kidney and activated by endogenous danger signals.
Positive_regulation (activated) of Gene_expression (expressed) of Toll-like receptor 2 in kidney
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682651 Disease Relevance 1.06 Pain Relevance 0.26
We found a clear increase in TLR2 protein expression in patients with progressive renal injury as well as an increase in TLR2 mRNA and protein through a time course of UUO with a prominent change in the distribution pattern.
Spec (clear) Positive_regulation (increase) of Gene_expression (expression) of TLR2 protein associated with hydronephrosis, ureteral obstruction and injury
4) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 3.03 Pain Relevance 0.30
Our studies demonstrate that the activation TLR2 expressed on B16 cells not only determines the invasiveness of these cells, but also facilitates tumor metastasis due to promoting the formation of the immunosuppressive microenvironment.
Positive_regulation (activation) of Gene_expression (expressed) of TLR2 associated with metastasis
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.51 Pain Relevance 0.22
Activation of TLR2 by LPS significantly enhanced the expression of TLR2 on these cells (Figure S1E).
Positive_regulation (enhanced) of Gene_expression (expression) of TLR2
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.19 Pain Relevance 0.19
TLR2 expression on bone marrow-derived DCs (BMDC) was necessary to stimulate a systemic antiglioma immune response.
Positive_regulation (necessary) of Gene_expression (expression) of TLR2 in bone marrow
7) Confidence 0.46 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.20 Pain Relevance 0.13
Of note, we have not been able to detect a direct effect of rhBCL2 or rhBCL2A1 on apoptosis in vitro in HEK TLR2 transfectants challenged with etoposide or in a myeloid cell line subjected to growth factor deprivation (Figs.
Positive_regulation (transfectants) of Gene_expression (transfectants) of TLR2 in myeloid cell associated with apoptosis
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.92 Pain Relevance 0.07
As shown in Fig. 3A, NTHi-induced COX-2 expression was significantly enhanced by overexpressing TLR2, but not by overexpressing TLR4.
Neg (not) Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TLR2 associated with hemophilus infection
9) Confidence 0.44 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.39 Pain Relevance 0.03
In ECs and epithelial cells the TLR2 expression is low [27], but can be upregulated [43].
Positive_regulation (upregulated) of Gene_expression (expression) of TLR2 in epithelial cells
10) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.84 Pain Relevance 0.08
Transfection of cells with Stat3C (S3C, Method S3) maintains Stat3 at a highly activated status [16]; TLR2 knockdown did not change the expression of proteins in S3C-transfected B16 cells (Fig.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of TLR2
11) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.25 Pain Relevance 0.04
The fold changes in TLR2 and TLR4 levels with HSP70 stimulation were higher in patients with AMI (both local and systemic samples) compared with patients with SA and controls (Figure 4).
Positive_regulation (stimulation) of Gene_expression (levels) of TLR2
12) Confidence 0.42 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.08 Pain Relevance 0
Blocking TLR2 reversed B16 cell-induced inhibitory immune microenvironment
Positive_regulation (reversed) of Gene_expression (reversed) of TLR2
13) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.47 Pain Relevance 0.04
Nevertheless, high upregulation following infection of both TLR2 and TLR13 in astrocytes and their foot processes that terminate at blood vessels may provide necessary signals for initiation of infiltration of immune cells to the CNS and the subsequent adaptive immune response [46].
Positive_regulation (upregulation) of Gene_expression (infection) of TLR2 in blood vessels associated with central nervous system and infection
14) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.21 Pain Relevance 0.23
To further investigate the role of TLR2 and TLR4 in NTHi-induced COX-2 expression in vivo, wild type, and TLR2 and TLR4 knock-out mice were intratracheally inoculated with 1 × 107 CFU of NTHi strain 12, and mRNA expression of COX-2 in lungs of infected mice were measured by Q-PCR analysis 6 h after inoculation.
Positive_regulation (induced) of Gene_expression (expression) of TLR2 in lungs associated with targeted disruption, hemophilus infection and sprains and strains
15) Confidence 0.32 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.46 Pain Relevance 0.03
Given the fact that TLR2 and TLR4 are of particular important in NTHi-induced signaling pathway and gram-negative bacteria-initiated signaling pathway in lung epithelial cells, respectively, we investigated the possible involvement of TLR2 and TLR4 in NTHi-induced COX-2 expression in vitro by using HEK293 cells overexpressing TLR2 or TLR4.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TLR2 in lung associated with hemophilus infection
16) Confidence 0.32 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.32 Pain Relevance 0.04
Taken advantages of stably overexpressing TLR2 and TLR4 cells and TLR2 and TLR4 knock-out mice, we showed here that NTHi-induced COX-2 expression was mediated by TLR2 signaling pathway both in vitro and in vivo, but independently from TLR4.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TLR2 associated with targeted disruption and hemophilus infection
17) Confidence 0.32 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.98 Pain Relevance 0.06
The expression of TLR2 was more prominent in the DEP-OC + LPS and the washed DEP + LPS groups than in the LPS group.
Positive_regulation (prominent) of Gene_expression (expression) of TLR2
18) Confidence 0.31 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.27 Pain Relevance 0.07
into the hippocampus provokes TLR2 gene expression [88].
Positive_regulation (provokes) of Gene_expression (expression) of TLR2 in hippocampus associated with hippocampus
19) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.82 Pain Relevance 0.14
An examination of TLR expression in the brain revealed that there was increased expression of CD14, TLR2, and TLR4 in AD human brains and animal models [41, 84–86].
Positive_regulation (increased) of Gene_expression (expression) of TLR2 in brains associated with disease
20) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.95 Pain Relevance 0.15

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