INT142606

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 6.15
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglial cells 10
CD86 6
B cells 2
SCs 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 133 100.00 Very High Very High Very High
Cannabinoid 66 100.00 Very High Very High Very High
aspirin 41 100.00 Very High Very High Very High
Cannabinoid receptor 30 97.84 Very High Very High Very High
Inflammation 170 95.24 Very High Very High Very High
imagery 45 91.44 High High
cytokine 116 88.52 High High
chemokine 25 86.44 High High
Neuritis 5 84.40 Quite High
Inflammatory mediators 12 82.88 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 36 99.50 Very High Very High Very High
Infection 61 98.70 Very High Very High Very High
Multiple Sclerosis 80 98.12 Very High Very High Very High
Neurodegenerative Disease 43 95.48 Very High Very High Very High
Alzheimer's Dementia 45 95.36 Very High Very High Very High
INFLAMMATION 194 95.24 Very High Very High Very High
Death 9 93.00 High High
Targeted Disruption 20 90.80 High High
Viral Infection 6 86.80 High High
Injury 15 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In that report, the authors showed that CD40 expression by parenchymal microglia was responsible for recruitment/retention of encephalitogenic T cells in EAE.
Regulation (responsible) of Gene_expression (expression) of CD40 in microglia associated with multiple sclerosis
1) Confidence 0.56 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.81 Pain Relevance 0.11
M may be the most efficacious concentration for regulating CD40 expression (Fig. 2C and 2D).
Regulation (regulating) of Gene_expression (expression) of CD40
2) Confidence 0.54 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0
We previously reported that mechanisms that antagonize microglial CD40 expression or CD40 signaling could also block microglial production of proinflammatory mediators [27].
Regulation (antagonize) of Gene_expression (expression) of CD40
3) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.31 Pain Relevance 0.28
-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.
Regulation (regulation) of Gene_expression (expression) of CD40 in microglial cells
4) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.29 Pain Relevance 0.30
Furthermore, Western blotting examination consistently showed that JWH-015 co-treatment mitigates the inducible increase in CD40 protein expression in primary cultured microglial cells after IFN-?
Regulation (after) of Gene_expression (expression) of CD40 in microglial cells
5) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
We previously reported that mechanisms that antagonize microglial CD40 expression or CD40 signaling could also block microglial production of proinflammatory mediators [27].
Regulation (antagonize) of Gene_expression (expression) of CD40
6) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.31 Pain Relevance 0.28
We have previously reported that microglial CD40 expression is significantly increased by IFN-?
Regulation (microglial) of Gene_expression (expression) of CD40
7) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.55 Pain Relevance 0.26
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Regulation (evaluated) of Gene_expression (expression) of CD40 in B cells
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
The increased MHC-II and CD40 expression on SCs was accompanied by lower levels of intracellular IL-6 production within SCs of apoE deficiency, which is confirmed by the neutralization with anti IL-6 antibody.
Regulation (accompanied) of Gene_expression (expression) of CD40 in SCs
9) Confidence 0.30 Published 2007 Journal Glia Section Abstract Doc Link 17357152 Disease Relevance 0.90 Pain Relevance 0.41
The results suggested that E2 could enhance the PDCs' activation and maturation by changing the CD40 and CD86 expression.


Regulation (changing) of Gene_expression (expression) of CD40 in CD86
10) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.17 Pain Relevance 0
In this study, we investigated the effects of a cannabinoid agonist on CD40 expression and function by cultured microglial cells activated by IFN-?
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CD40 in microglial cells associated with cannabinoid and agonist
11) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.74 Pain Relevance 0.55
To investigate cannabinoid regulation of CD40 expression in microglial cells, primary cultured murine microglial cells were treated with IFN-?
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of CD40 in microglial cells associated with cannabinoid
12) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
Again a great difference was observed among the LAB strains in their capacity to up-regulate the expression of MHC class II and co-stimulatory molecules (CD86, CD40) (Fig. 3).
Regulation (regulate) of Gene_expression (expression) of CD40 in CD86 associated with sprains and strains
13) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.31 Pain Relevance 0.45
In an experimental model of JEV infection, we have observed that the Nestin positive cells express and up-regulate the expression of costimulatory molecules, CD40, CD80 and CD86 on their surface.
Regulation (regulate) of Gene_expression (expression) of CD40 in CD86 associated with infection
14) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.49 Pain Relevance 0.09
Flow cytometric analysis for major co-stimulatory molecules such as B7-1, B7-2, and CD40 also showed that aspirin did not affect the expression of these co-stimulatory molecules (Fig. 6).
Neg (not) Regulation (affect) of Gene_expression (expression) of CD40 associated with aspirin
15) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0 Pain Relevance 0.24

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