INT142607

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 13.85
Pain Relevance 5.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglial cells 14
CD86 14
T cells 10
bone marrow 4
macrophages 3
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 229 99.98 Very High Very High Very High
Pain 19 99.16 Very High Very High Very High
Neuropeptide 10 98.80 Very High Very High Very High
Cannabinoid receptor 50 98.68 Very High Very High Very High
cytokine 254 97.60 Very High Very High Very High
Inflammation 359 97.18 Very High Very High Very High
aspirin 41 94.00 High High
Arthritis 103 93.28 High High
Inflammatory response 21 87.64 High High
rheumatoid arthritis 62 87.20 High High
Disease Link Frequency Relevance Heat
Eye Disease 63 99.80 Very High Very High Very High
Influenza Virus Infection 81 99.70 Very High Very High Very High
Infection 131 99.50 Very High Very High Very High
Sprains And Strains 37 99.50 Very High Very High Very High
Drug Induced Neurotoxicity 10 99.36 Very High Very High Very High
Pain 19 99.16 Very High Very High Very High
Mixed Connective Tissue Disorder 70 99.06 Very High Very High Very High
Fatigue 15 99.00 Very High Very High Very High
Disease 398 97.60 Very High Very High Very High
INFLAMMATION 415 97.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
peptide and enhanced CD40 expression on microglial cells derived from the Tg2576 mouse model of AD [28].
Positive_regulation (enhanced) of Gene_expression (expression) of CD40 in microglial cells associated with disease
1) Confidence 0.62 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.78 Pain Relevance 0.29
-induced CD40 expression in a dose-related manner (Figure. 1B).
Positive_regulation (induced) of Gene_expression (expression) of CD40
2) Confidence 0.62 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.09
signaling pathway to induce microglial CD40 expression and subsequent neurotoxicity [28].
Positive_regulation (induce) of Gene_expression (expression) of CD40 associated with drug induced neurotoxicity
3) Confidence 0.62 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.81 Pain Relevance 0.31
Our preliminary results from patients with uncharacteristic inflammatory disorders (n = 11, 8 females and 3 males), as defined by for example long-standing fatigue or pain, and no more specific diagnosis, show an elevated monocyte CD40 expression in most, but not all, cases (mean value 6 times higher than normal controls); an increased fraction of the CD14+ CD16+ monocyte subset (15% of all monocytes); and a most diverse T lymphocyte pattern.
Positive_regulation (elevated) of Gene_expression (expression) of CD40 in T lymphocyte associated with pain, inflammation and fatigue
4) Confidence 0.57 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.59 Pain Relevance 0.15
At Day 6 of culture, bone marrow-derived DCs from DBA/1 LacJ mice were transfected with CD40 siRNA or control siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of CD40 siRNA in bone marrow
5) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0 Pain Relevance 0
DCs were generated from bone marrow progenitors by standard IL-4 and GM-CSF culture and transfected on Day 6 with CD40-siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of CD40-siRNA in bone marrow
6) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.27 Pain Relevance 0.08
To test this hypothesis, we used CD40-silenced DCs as allostimulators in MLR.
Positive_regulation (used) of Gene_expression (used) of CD40-silenced
7) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.26 Pain Relevance 0.06
-induced CD40 expression in the immature murine DC cell line, BC1 (Iijima et al., 2003), and blocked the expression of high levels of surface molecules such as MHCs, B7-1, and B7-2 after lipopolysaccharide treatment in human DC (Nouri-Shirazi & Guinet, 2002).
Positive_regulation (induced) of Gene_expression (expression) of CD40
8) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Amaya lparraguirre reported that although both influenza virus and CpG led to increased expression levels of costimulatory molecules on PDCs, including CD40 and CD86 as well as MHC II, an exception was CD80, which was expressed to the lower extend under the CpG stimuli than the influenza virus stimuli [38].
Positive_regulation (led) of Gene_expression (expression) of CD40 in CD86 associated with influenza virus infection
9) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.33 Pain Relevance 0
However, when combination of both E2 and CpG was used, the enhancements of CD40 and CD86 expression were more strikingly than CpG alone (Figure 2 and Figure S4).
Positive_regulation (enhancements) of Gene_expression (expression) of CD40 in CD86
10) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.14 Pain Relevance 0
-induced microglial CD40 expression do so by modification of the JAK/STAT pathway [34-39].
Positive_regulation (induced) of Gene_expression (expression) of CD40
11) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.07 Pain Relevance 0.23
Furthermore, Western blotting examination consistently showed that JWH-015 co-treatment mitigates the inducible increase in CD40 protein expression in primary cultured microglial cells after IFN-?
Positive_regulation (increase) of Gene_expression (expression) of CD40 in microglial cells
12) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
To examine the functional consequences of CB2 agonist treatment on CD40 expression, we stimulated mouse primary microglial cells with either IFN-?
Spec (examine) Positive_regulation (treatment) of Gene_expression (expression) of CD40 in microglial cells associated with agonist
13) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.19 Pain Relevance 0.22
-induced microglial CD40 expression by opposing JAK/STAT1 pathway activation.
Positive_regulation (induced) of Gene_expression (expression) of CD40
14) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.73 Pain Relevance 0.28
Flow cytometric analysis of microglial CD40 expression
Positive_regulation (microglial) of Gene_expression (expression) of CD40
15) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0 Pain Relevance 0
, which consequently sensitizes the microglia by upregulating the expression of various immunoregulatory molecules, including CD40, on their cell surfaces [23,24].
Positive_regulation (upregulating) of Gene_expression (expression) of CD40 in microglia
16) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.93 Pain Relevance 0.25
-induced microglial CD40 expression [25,26].
Positive_regulation (induced) of Gene_expression (expression) of CD40
17) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.84 Pain Relevance 0.25
-induced CD40 expression in microglial cells
Positive_regulation (induced) of Gene_expression (expression) of CD40 in microglial cells
18) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.04
-induced CD40 expression.
Positive_regulation (induced) of Gene_expression (expression) of CD40
19) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.56 Pain Relevance 0.49
to potently induce microglial CD40 expression [28].
Positive_regulation (induce) of Gene_expression (expression) of CD40
20) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.08 Pain Relevance 0.19

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