INT142626

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.63
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
hepatocyte 2
urine 2
kidney 2
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 27 99.98 Very High Very High Very High
Inflammation 13 87.20 High High
ischemia 7 79.80 Quite High
tolerance 23 54.72 Quite High
alcohol 4 33.76 Quite Low
Calcium channel 15 18.28 Low Low
antagonist 7 6.80 Low Low
aspirin 28 5.00 Very Low Very Low Very Low
beta blocker 13 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 185 99.84 Very High Very High Very High
Diabetes Mellitus 829 99.32 Very High Very High Very High
Renal Disease 71 98.72 Very High Very High Very High
Albuminuria 35 93.64 High High
Adhesions 2 92.32 High High
Diabetes Complications 13 92.08 High High
Disease 26 91.84 High High
Hypotension 15 90.88 High High
Hepatotoxicity 3 89.84 High High
INFLAMMATION 17 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretion.
Negative_regulation (reduces) of Localization (secretion) of albumin in hepatocyte associated with paracetamol
1) Confidence 0.55 Published 2007 Journal ALTEX Section Title Doc Link 17361319 Disease Relevance 0.06 Pain Relevance 0.62
High doses of AAP (2815 mg/l) diminished urea production by 15-30% and albumin secretion by 70-80%.
Negative_regulation (diminished) of Localization (secretion) of albumin associated with paracetamol
2) Confidence 0.55 Published 2007 Journal ALTEX Section Abstract Doc Link 17361319 Disease Relevance 0.09 Pain Relevance 0.87
These two drug classes have nearly identical effects on the renin-angiotensin system and are known to reduce urinary albumin excretion and protect the kidney against diabetic nephropathy.
Negative_regulation (reduce) of Localization (excretion) of albumin in kidney associated with renal disease
3) Confidence 0.31 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2571054 Disease Relevance 1.89 Pain Relevance 0.13
Whereas high doses of AAP (2815 mg/l) diminished albumin secretion by 70-80%.
Negative_regulation (diminished) of Localization (secretion) of albumin associated with paracetamol
4) Confidence 0.29 Published 2007 Journal ALTEX Section Abstract Doc Link 17361318 Disease Relevance 0.16 Pain Relevance 0.59
However, another recently published trial in hypertensive patients with type 2 diabetes152 showed that adding manidipine on top of RAS blocker, candesartan, reduced the urinary albumin excretion by 53%, while thiazide diuretic add-on was ineffective.
Negative_regulation (reduced) of Localization (excretion) of albumin associated with hypertension
5) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.37 Pain Relevance 0
Urinary albumin excretion was reduced by 65.5% with manidipine versus 20% with amlodipine at 6 months (p < 0.01), and by 62.7 versus 16.6% (p < 0.01) at 24 months, confirming the peculiar effects on glomerular hemodynamics of the latest generation of dihydropyridines.
Negative_regulation (reduced) of Localization (excretion) of albumin
6) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.41 Pain Relevance 0
Ala12 allele carriers also have significantly reduced urinary albumin excretion than noncarriers and the reduction becomes even more dramatic along with increased duration of diabetes [154, 170].
Negative_regulation (reduced) of Localization (excretion) of albumin associated with diabetes mellitus
7) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 2.04 Pain Relevance 0.03
Nonetheless, Fogari et al50 showed that the amlodipine/telmisartan combination has been very useful in decreasing urinary albumin excretion in hypertensive diabetic patients with microalbuminuria.
Negative_regulation (decreasing) of Localization (excretion) of albumin associated with diabetes mellitus and hypertension
8) Confidence 0.05 Published 2010 Journal Core evidence Section Body Doc Link PMC2899780 Disease Relevance 0.68 Pain Relevance 0
Studies have found decreased GFR in the absence of increased urine albumin excretion in a substantial percentage of adults with diabetes (285,286).
Negative_regulation (decreased) of Localization (excretion) of albumin in urine associated with diabetes mellitus
9) Confidence 0.04 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.93 Pain Relevance 0

General Comments

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