INT142637

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2003
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.23
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) plasma membrane (PRTN3)
enzyme binding (PRTN3)
Anatomy Link Frequency
synovium 4
ankle joint 2
T cells 2
nasal septum 1
neutrophil 1
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 4 100.00 Very High Very High Very High
rheumatoid arthritis 301 99.84 Very High Very High Very High
cytokine 23 99.38 Very High Very High Very High
Pain 11 93.92 High High
metalloproteinase 58 93.20 High High
Inflammation 31 81.96 Quite High
Arthritis 23 72.16 Quite High
corticosteroid 2 38.40 Quite Low
cINOD 3 25.00 Low Low
abatacept 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 301 99.84 Very High Very High Very High
Confusion 1 99.48 Very High Very High Very High
Disease 112 99.32 Very High Very High Very High
Myeloid Leukemia 82 99.20 Very High Very High Very High
Apoptosis 15 98.12 Very High Very High Very High
Cocaine Dependence 1 97.32 Very High Very High Very High
Nasal Obstruction 1 95.24 Very High Very High Very High
Pain 11 93.92 High High
Renal Disease 1 89.84 High High
Toxicity 6 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the precise causes of the disease and of the initial immune process leading to cANCA production remain unknown.
Positive_regulation (leading) of Gene_expression (production) of cANCA associated with disease
1) Confidence 0.46 Published 2007 Journal Presse Med Section Abstract Doc Link 17363211 Disease Relevance 0.41 Pain Relevance 0.08
[A patient with both cocaine-induced nasal septum destruction and antibodies against anti-neutrophil cytoplasmic antibodies (ANCA); potential confusion with Wegener's disease].
Positive_regulation (cocaine-induced) of in nasal septum Gene_expression (antibodies) of ANCA in neutrophil associated with disease, confusion and cocaine
2) Confidence 0.43 Published 2007 Journal Ned Tijdschr Geneeskd Section Title Doc Link 18019218 Disease Relevance 0.93 Pain Relevance 0.30
MBT sandals produce a statistically significant increase in frontal and sagittal plane ranges of motion of the subtalar and ankle joint complex during gait.
Positive_regulation (increase) of Gene_expression (produce) of MBT in ankle joint
3) Confidence 0.43 Published 2011 Journal J Foot Ankle Res Section Body Doc Link PMC3024926 Disease Relevance 0.08 Pain Relevance 0
Rheumatoid factor versus ACPA in RA
Positive_regulation (versus) of Gene_expression (versus) of ACPA associated with rheumatoid arthritis
4) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.08 Pain Relevance 0.28
On the other hand, there is no evidence suggesting that the ACPA prevalence increases with increasing disease duration.
Positive_regulation (increases) of Gene_expression (prevalence) of ACPA associated with disease
5) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.17 Pain Relevance 0.42
This may be due to apoptosis of high-avidity T cells induced by exposure to high peptide concentrations or leukemic cells overexpressing the proteinase 3 [78].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of proteinase 3 in T cells associated with apoptosis
6) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.75 Pain Relevance 0
Proteinase 3 is a differentiation antigen that is also overexpressed in leukemic blasts [78].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Proteinase 3
7) Confidence 0.17 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.80 Pain Relevance 0
To test whether these B cells were derived from AID-expressing cells resident in the synovium rather than ACPA-expressing immune system cells coming into the synovium from elsewhere in the body, the researchers transplanted synovium from patients with rheumatoid arthritis under the skin of a special sort of mouse that largely lacks its own immune system.
Spec (whether) Positive_regulation (derived) of Gene_expression (expressing) of ACPA in synovium associated with rheumatoid arthritis
8) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621263 Disease Relevance 0.43 Pain Relevance 0.15
It is important to emphasise that these experiments cannot formally exclude the possibility that pre-existing long-lived plasma cells, either generated in situ or migrated from secondary lymphoid organs, might also contribute to the production of ACPA in RA synovium and in transplanted animals.
Spec (might) Positive_regulation (contribute) of Gene_expression (production) of ACPA in synovium associated with rheumatoid arthritis
9) Confidence 0.13 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.38 Pain Relevance 0.19
This will require detailed analysis of the signalling pathways involved in transforming a cytokine signal at the cell surface to induce the expression of proteinase or inhibitor.
Positive_regulation (induce) of Gene_expression (expression) of proteinase associated with cytokine
10) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.20 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox