INT14264

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Context Info
Confidence 0.47
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 39
Total Number 39
Disease Relevance 5.70
Pain Relevance 14.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
M15 3
spinal cord 2
nerve 2
plasma 1
lactotrophs 1
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 47 100.00 Very High Very High Very High
Serotonin 7 100.00 Very High Very High Very High
allodynia 5 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
Spinal sensitization 1 100.00 Very High Very High Very High
Neuropeptide 44 99.98 Very High Very High Very High
Cholecystokinin 6 99.92 Very High Very High Very High
Hippocampus 10 99.88 Very High Very High Very High
Opioid 5 99.80 Very High Very High Very High
Morphine 28 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 11 100.00 Very High Very High Very High
Nervous System Injury 5 99.72 Very High Very High Very High
Nociception 11 99.34 Very High Very High Very High
Urological Neuroanatomy 5 99.04 Very High Very High Very High
Sleep Disorders 1 98.96 Very High Very High Very High
Depression 10 95.20 Very High Very High Very High
Pressure And Volume Under Development 9 95.20 Very High Very High Very High
Hyperalgesia 3 94.48 High High
INFLAMMATION 29 92.60 High High
Neurodegenerative Disease 5 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biocompatibility studies showed that the microspheres crosslinked with GAL are well tolerated in vivo.
GAL Binding (crosslinked) of
1) Confidence 0.47 Published 2001 Journal Int J Pharm Section Abstract Doc Link 11250103 Disease Relevance 0.14 Pain Relevance 0.15
In rat, the intrathecal administration of the peptide-PNA construct results in a decrease in galanin binding in the dorsal horn.
galanin Binding (binding) of in dorsal horn associated with dorsal horn and intrathecal
2) Confidence 0.47 Published 1998 Journal Nat. Biotechnol. Section Abstract Doc Link 9743120 Disease Relevance 0.07 Pain Relevance 0.17
Rat galanin and galanin-related peptides M40, C7, M15, and galanin effectively competed for binding; peptide C7 demonstrated a lower affinity for rGALR-2, and all these peptides were agonists at rGALR-2 when assessed on a microphysiometer.
galanin Binding (affinity) of in M15 associated with agonist
3) Confidence 0.47 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928164 Disease Relevance 0.07 Pain Relevance 0.21
Rat galanin and galanin-related peptides M40, C7, M15, and galanin effectively competed for binding; peptide C7 demonstrated a lower affinity for rGALR-2, and all these peptides were agonists at rGALR-2 when assessed on a microphysiometer.
galanin Binding (binding) of in M15 associated with agonist
4) Confidence 0.47 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928164 Disease Relevance 0.07 Pain Relevance 0.20
Our aim was to investigate whether also endogenous galanin interacts with an exogenously administered opioid, morphine, in the rat spinal cord.
galanin Binding (interacts) of in spinal cord associated with opioid, spinal cord and morphine
5) Confidence 0.46 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7531294 Disease Relevance 0.21 Pain Relevance 1.02
our present findings such that there would be a possibility of mapping the residues proposed by us for the prediction of the binding site of galanin.



galanin Binding (binding) of
6) Confidence 0.39 Published 2006 Journal Bioinformation Section Body Doc Link PMC1891676 Disease Relevance 0.15 Pain Relevance 0.06
The interaction between intrathecally (i.t.) applied galanin (GAL) and morphine was examined in electrophysiological and behavioural experiments.
GAL Binding (interaction) of associated with morphine
7) Confidence 0.37 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1690366 Disease Relevance 0.12 Pain Relevance 0.49
Intracisternal injections of galanin and NPY were performed 2 weeks after nerve injury and mechanical allodynia was monitored.
galanin Binding (injections) of in nerve associated with nervous system injury and allodynia
8) Confidence 0.37 Published 2009 Journal Int. J. Neurosci. Section Abstract Doc Link 19922394 Disease Relevance 0.60 Pain Relevance 0.67
These results indicate an anti-nociceptive role of galanin, and a possible interaction between galanin and opioid peptides in PAG in rats.
galanin Binding (interaction) of associated with nociception, periaqueductal grey and opioid
9) Confidence 0.36 Published 1999 Journal Brain Res. Section Abstract Doc Link 10407105 Disease Relevance 0.71 Pain Relevance 0.41
I.t. galanin significantly alleviated the mechanical- and cold-allodynia-like behaviours in nerve injured rats, and was not associated with motor impairment or sedation.
galanin Binding (associated) of in nerve associated with allodynia and sleep disorders
10) Confidence 0.36 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10051743 Disease Relevance 0.94 Pain Relevance 0.76
The interaction between intrathecally (i.t.) applied galanin (GAL) and morphine was examined in electrophysiological and behavioural experiments.
galanin Binding (interaction) of associated with morphine
11) Confidence 0.36 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1690366 Disease Relevance 0.12 Pain Relevance 0.49
It is further shown that galanin, a naturally occurring neuropeptide present in primary afferents, also inhibits C-fiber activation-evoked plasma extravasation, indicating an interaction between galanin and tachykinins in the peripheral terminals of primary afferents, possibly through both pre- and postsynaptic mechanisms.
galanin Binding (interaction) of in plasma associated with c fibre and neuropeptide
12) Confidence 0.36 Published 1991 Journal Neuroscience Section Abstract Doc Link 1720225 Disease Relevance 0.09 Pain Relevance 0.62
The maximal inhibitory effect of galanin in slices or synaptosomes was lower than that previously reported for histamine acting at H3-autoreceptors, possibly suggesting that not all histaminergic axon terminals, even in the hypothalamus and hippocampus, are endowed with galanin receptors.
galanin Binding (endowed) of in hippocampus associated with hippocampus
13) Confidence 0.36 Published 1991 Journal Peptides Section Abstract Doc Link 1724798 Disease Relevance 0 Pain Relevance 0.29
Both galanin-(-7-29) and galanin-(-9-29) fully displaced specific 125I-monoido-[Tyr26]porcine galanin (125I-galanin) binding to membranes prepared from rat dorsal spinal cord, with IC50 values 0.13 and 0.14 microM, respectively.
galanin Binding (binding) of in spinal cord associated with spinal cord
14) Confidence 0.36 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7525314 Disease Relevance 0 Pain Relevance 0.38
Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region.
Gal Binding (interaction) of associated with neuropeptide
15) Confidence 0.36 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 1699553 Disease Relevance 0 Pain Relevance 0.62
Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region.
galanin Binding (interaction) of associated with neuropeptide
16) Confidence 0.36 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 1699553 Disease Relevance 0 Pain Relevance 0.62
Rat galanin and galanin-related peptides M40, C7, M15, and galanin effectively competed for binding; peptide C7 demonstrated a lower affinity for rGALR-2, and all these peptides were agonists at rGALR-2 when assessed on a microphysiometer.
galanin Binding (binding) of in M15 associated with agonist
17) Confidence 0.35 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928164 Disease Relevance 0.07 Pain Relevance 0.20
Molecular cloning and characterization of a new receptor for galanin.
galanin Binding (receptor) of
18) Confidence 0.34 Published 1997 Journal FEBS Lett. Section Title Doc Link 9108306 Disease Relevance 0 Pain Relevance 0.14
In the present study, we examined the possible interaction between GAL, CCK and clonidine, an alpha 2 adrenoceptor agonist and potent spinal antinociceptive agent, in the spinal nociceptive flexor reflex.
GAL Binding (interaction) of associated with nociception, agonist, antinociceptive, cholecystokinin and clonidine
19) Confidence 0.34 Published 1993 Journal Brain Res. Section Abstract Doc Link 7694763 Disease Relevance 0.32 Pain Relevance 1.51
such as prediction of theoretical models for galanin, studying its interaction through docking mechanisms etc.
galanin Binding (interaction) of
20) Confidence 0.34 Published 2006 Journal Bioinformation Section Body Doc Link PMC1891676 Disease Relevance 0.17 Pain Relevance 0.07

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