INT142677

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.09
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 24 98.26 Very High Very High Very High
Leflunomide 10 97.96 Very High Very High Very High
cytokine 5 91.88 High High
cINOD 18 76.56 Quite High
Analgesic 1 54.96 Quite High
antagonist 4 46.16 Quite Low
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
COX-2 inhibitor 10 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 8 100.00 Very High Very High Very High
Death 5 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Apoptosis 47 99.20 Very High Very High Very High
Toxicity 2 97.84 Very High Very High Very High
Cancer 90 94.52 High High
Necrosis 3 92.48 High High
Carcinoma 3 83.36 Quite High
Injury 2 75.00 Quite High
Lymphatic System Cancer 2 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, GrTP supplementation attenuated hepatotoxicity by normalizing Cox-2 and Bcl-2 activation, suggesting a potential use for GrTP in treatng APAP toxicity.
Negative_regulation (attenuated) of Positive_regulation (activation) of Bcl-2 associated with toxicity, paracetamol and hepatotoxicity
1) Confidence 0.36 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18373199 Disease Relevance 0.74 Pain Relevance 0.68
Instead, leflunomide inhibited APAP-induced activation (phosphorylation) of c-jun NH2-terminal protein kinase (JNK), thus preventing downstream Bcl-2 and Bcl-XL inactivation and protecting from mitochondrial permeabilization and cytochrome c release.
Negative_regulation (preventing) of Positive_regulation (inactivation) of Bcl-2 associated with paracetamol and leflunomide
2) Confidence 0.17 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.49 Pain Relevance 1.35
Moreover, it was already reported that tacrolimus prevented an increase in the Bax/Bcl-2 ratio following an apoptotic stimulus in U251 cells, while others found a reduction in mitochondrial Bax with the overall expression level remaining unchanged [19,20].
Negative_regulation (prevented) of Positive_regulation (increase) of Bcl-2 associated with apoptosis
3) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.63 Pain Relevance 0
Forced COX-2 expression significantly attenuated TRAIL-induced apoptosis and was associated with transcriptional repression of death receptor-5 and up-regulation of Bcl-2 [89].
Negative_regulation (repression) of Positive_regulation (regulation) of Bcl-2 associated with repression, apoptosis and death
4) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.22 Pain Relevance 0.21

General Comments

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