INT142679

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
kinase activity (Mapk9) transcription factor binding (Mapk9) cytoplasm (Mapk9)
Mapk9 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
Leflunomide 10 99.98 Very High Very High Very High
Analgesic 1 59.00 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 88.92 High High
Injury 2 75.00 Quite High
Death 1 70.92 Quite High
Toxicity 1 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, leflunomide inhibited APAP-induced activation (phosphorylation) of c-jun NH2-terminal protein kinase (JNK), thus preventing downstream Bcl-2 and Bcl-XL inactivation and protecting from mitochondrial permeabilization and cytochrome c release.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of c-jun NH2-terminal protein kinase associated with paracetamol and leflunomide
1) Confidence 0.17 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.51 Pain Relevance 1.37

General Comments

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