INT142682

Context Info Confidence 0.26 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.40 Pain Relevance 0.06

cell adhesion (EMR1) plasma membrane (EMR1) signal transducer activity (EMR1)

EMR1 (Homo sapiens)

Pain Link Frequency Relevance Heat headache 1 55.92 positron emission tomography 2 45.12 imagery 4 41.76 alcohol 4 25.40 Inflammation 3 25.00 Inflammatory response 1 25.00 cytokine 24 5.00 depression 2 5.00 fibrosis 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Disease 32 95.92 Cancer 179 95.16 Colon Cancer 5 87.68 Apoptosis 10 85.48 Lung Cancer 1 83.28 Papillomavirus Infection 22 71.60 Skin Allergy 2 61.28 Sprains And Strains 2 61.20 Exanthema 7 57.76 Diarrhoea 1 57.28

Sentences Mentioned In

Key:

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Disease term

Cetuximab is a human/mouse chimeric monoclonal antibody that binds to the EGF receptor, competitively inhibiting ligand binding, and inducing receptor dimerization and downregulation.

EGF receptor Binding (binds) of

1) Confidence 0.26 Published 2007 Journal Expert Opin Drug Saf Section Abstract Doc Link 17367263 Disease Relevance 0.87 Pain Relevance 0.06

A variety of EGFR inhibitors have been developed that function either by binding to the extracellular ligand binding domain of the EGF receptor (e.g., MAbs such as cetuximab), or by inhibiting the intracellular tyrosine kinase activity of the receptor [65, 66].

EGF receptor Binding (binding) of

2) Confidence 0.01 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 0.68 Pain Relevance 0

The monoclonal antibody (MAb) cetuximab, which binds to the EGF receptor, is approved by the US Food and Drug Administration as first-line treatment of locally or regionally advanced HNSCC in combination with radiotherapy.

EGF receptor Binding (binds) of

3) Confidence 0.01 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 0.85 Pain Relevance 0

General Comments

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