INT142684

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 9 99.80 Very High Very High Very High
analgesia 1 98.32 Very High Very High Very High
tolerance 1 97.88 Very High Very High Very High
addiction 1 97.28 Very High Very High Very High
Morphine 3 93.40 High High
Analgesic 2 92.64 High High
Opioid 1 83.40 Quite High
Pain 4 83.12 Quite High
opioid receptor 1 82.04 Quite High
drug abuse 1 80.28 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 1 90.88 High High
Targeted Disruption 1 89.48 High High
Drug Dependence 1 80.28 Quite High
Pain 3 74.68 Quite High
Cancer 1 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These polymorphisms might be correlated with OPRM1 mRNA stability and opiate sensitivity, including opiate analgesia, tolerance, and dependence.
Protein_catabolism (stability) of OPRM1 associated with addiction, tolerance, opiate and analgesia
1) Confidence 0.66 Published 2007 Journal Curr Pain Headache Rep Section Abstract Doc Link 17367590 Disease Relevance 0.48 Pain Relevance 1.57
However, alternative initiation of the long form of OPRM1 produces a protein with a short half-life, resulting from degradation mediated by the ubiquitin-proteasome pathway.
Protein_catabolism (degradation) of OPRM1
2) Confidence 0.58 Published 2009 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19609488 Disease Relevance 0 Pain Relevance 0.24

General Comments

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