INT142690

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.54
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 10
sciatic nerve 2
DRG 2
dorsal horn 2
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 194 100.00 Very High Very High Very High
hyperexcitability 37 100.00 Very High Very High Very High
Sciatic nerve 55 99.70 Very High Very High Very High
Thermal hyperalgesia 4 99.42 Very High Very High Very High
Inflammation 47 99.40 Very High Very High Very High
Eae 22 98.46 Very High Very High Very High
Dorsal horn 6 95.68 Very High Very High Very High
Hyperalgesia 14 92.56 High High
addiction 74 92.32 High High
pregabalin 6 91.72 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 198 100.00 Very High Very High Very High
Injury 48 99.82 Very High Very High Very High
Hyperalgesia 20 99.42 Very High Very High Very High
INFLAMMATION 60 99.40 Very High Very High Very High
Erythermalgia 82 98.54 Very High Very High Very High
Nerve Compression Syndromes 31 95.40 Very High Very High Very High
Pain 116 90.08 High High
Somatoform Disorder 187 89.84 High High
Diabetes Mellitus 88 89.20 High High
Multiple Trauma 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that increased DRG mRNA production leads to increased alpha 2 delta 1 protein production and subsequent transport by primary afferents to the dorsal horn.
Positive_regulation (increased) of Gene_expression (production) of DRG in dorsal horn associated with dorsal root ganglion and dorsal horn
1) Confidence 0.23 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17367933 Disease Relevance 0.92 Pain Relevance 1.16
We directly tested whether ranolazine could reduce excitability of DRG neurons transfected with either WT or the hyperexcitability-inducing mutations L858H or V1298F.
Positive_regulation (transfected) of Gene_expression (transfected) of DRG in neurons associated with dorsal root ganglion and hyperexcitability
2) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.65 Pain Relevance 0.63
Transfection of DRG neurons
Positive_regulation (Transfection) of Gene_expression (Transfection) of DRG in neurons associated with dorsal root ganglion
3) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.19 Pain Relevance 0.09
Either WT hNav1.7R or M1627K mutant channels were transiently transfected into the DRG neurons, along with enhanced-GFP, by electroporation with a Nucleofector II (Amaxa, Gaithersburg, MD) using Rat Neuron Nucleofector Solution and program G-013.
Positive_regulation (transfected) of Gene_expression (transfected) of DRG in Neuron associated with dorsal root ganglion
4) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.25 Pain Relevance 0.17
Student's t-test was used to assess the significance (p < 0.05) of differences between parameters measured from DRG neurons transfected with WT or M1627K mutant channels.
Positive_regulation (transfected) of Gene_expression (transfected) of DRG in neurons associated with dorsal root ganglion
5) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.10 Pain Relevance 0.14
However, Harty et al [13,16,17] have shown that depolarization of RMP produced by an IEM mutation (A863P) contributes to, but is not solely responsible for, the increase in DRG neuron hyperexcitability produced by that mutation.
Positive_regulation (increase) of Gene_expression (produced) of DRG neuron in neuron associated with dorsal root ganglion, erythermalgia and hyperexcitability
6) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.99 Pain Relevance 0.96
TRPV1 plays an essential role in development of inflammatory thermal hyperalgesia after tissue injury and its expression in rat lumbar DRG is increased after hindpaw inflammation.
Positive_regulation (increased) of Gene_expression (expression) of DRG in DRG associated with inflammation, thermal hyperalgesia and injury
7) Confidence 0.03 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.09 Pain Relevance 0.59
Similar post-CCI immunohistochemical redistribution of NaV1.8 to sciatic nerve axons without increased DRG mRNA expression previously led Novakovic et al. to suggest peripheral trafficking of existing NaV1.8 protein with increased local insertion [11].
Neg (without) Positive_regulation (increased) of Gene_expression (expression) of DRG mRNA in sciatic nerve associated with dorsal root ganglion, eae and sciatic nerve
8) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 2.02 Pain Relevance 0.80
In contrast to their findings, we detected increased DRG expression of TNF-?
Positive_regulation (detected) of Gene_expression (expression) of DRG
9) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.17 Pain Relevance 0.58
In contrast to their findings, we detected increased DRG expression of TNF-?
Positive_regulation (increased) of Gene_expression (expression) of DRG
10) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.17 Pain Relevance 0.58

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