INT142692

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
dorsal root ganglia 2
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
epidural 1 99.38 Very High Very High Very High
allodynia 2 96.96 Very High Very High Very High
Brush evoked pain 1 92.68 High High
Pain 2 84.56 Quite High
sodium channel 5 75.00 Quite High
tetrodotoxin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 96.96 Very High Very High Very High
Injury 4 96.44 Very High Very High Very High
Nociception 1 59.12 Quite High
Pain 2 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The siRNA, which was delivered to lumbar dorsal root ganglia (DRG) via an indwelling epidural cannula, caused a significant reduction of Na(V)1.8 mRNA expression in lumbar 4 and 5 (L4-L5) DRG neurons and consequently reversed mechanical allodynia in CCI rats.
Negative_regulation (reduction) of Transcription (expression) of Na(V)1.8 in dorsal root ganglia associated with allodynia, injury and epidural
1) Confidence 0.42 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.74 Pain Relevance 0.66

General Comments

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