INT142694

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 19
Disease Relevance 2.78
Pain Relevance 8.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PGAP1) nuclease activity (PGAP1)
Anatomy Link Frequency
myocardium 6
heart 4
myocytes 2
PGAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1054 100.00 Very High Very High Very High
bradykinin 697 100.00 Very High Very High Very High
isoflurane 102 99.98 Very High Very High Very High
ischemia 17 99.74 Very High Very High Very High
b2 receptor 51 94.40 High High
antagonist 85 92.36 High High
backache 52 91.48 High High
Opioid 17 86.08 High High
Pain management 3 67.64 Quite High
anesthesia 17 65.44 Quite High
Disease Link Frequency Relevance Heat
Syndrome 9 100.00 Very High Very High Very High
Cv Unclassified Under Development 17 99.74 Very High Very High Very High
Injury 17 99.16 Very High Very High Very High
Low Back Pain 60 91.48 High High
Reperfusion Injury 17 87.76 High High
Hypoxia 136 81.84 Quite High
Necrosis 17 81.64 Quite High
Myocardial Infarction 17 79.76 Quite High
Targeted Disruption 17 74.40 Quite High
Myalgia 2 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the categories of back disorders there was a shift from specific to non-specific diagnoses and an increase in post-laminectomy syndrome.
Positive_regulation (increase) of post-laminectomy syndrome associated with syndrome
1) Confidence 0.08 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1539006 Disease Relevance 0.34 Pain Relevance 0.24
The resting EMG activity increased at Post1 and Post2 (P<0.05).
Positive_regulation (increased) of Post1
2) Confidence 0.06 Published 2007 Journal Clin Neurophysiol Section Body Doc Link 17368095 Disease Relevance 0.07 Pain Relevance 0
At present, the involvement of adenosine and bradykinin receptors in anesthetic-induced PostC remains unknown, whereas these receptors were shown to be involved in anesthetic-induced preconditioning [12].
Positive_regulation (induced) of PostC associated with adenocard and bradykinin
3) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.23 Pain Relevance 0.54
At present, only two studies have shown, in mouse and rat heart, that isoflurane and sevoflurane-induced PostC was abolished by treatment with ROS scavengers [3,8].
Positive_regulation (induced) of PostC in heart associated with isoflurane
4) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.08 Pain Relevance 0.49
We have shown that stimulation of adenosine and bradykinin B2 receptors and ROS generation, during early reoxygenation, were involved in desflurane-induced PostC in human myocardium, in vitro.
Positive_regulation (induced) of PostC in myocardium associated with adenocard and bradykinin
5) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.27 Pain Relevance 0.22
The role of adenosine and bradykinin receptors' stimulation in desflurane-induced PostC was studied here for the first time using human myocardium.
Positive_regulation (induced) of PostC in myocardium associated with adenocard and bradykinin
6) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.06 Pain Relevance 0.41
Mechanisms involved in desflurane-induced PostC were studied in presence of desflurane 6%, because we have previously shown that 6% was effective to induce PostC in human myocardium, in vitro.7 In separate groups exposed to 6% desflurane during the first 5-min of reoxygenation in the presence of 150 ?
Positive_regulation (induce) of PostC in myocardium
7) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.20 Pain Relevance 0.15
Anesthetic-induced postconditioning (PostC) is a phenomenon whereby a brief exposure of the myocardium to a volatile halogenated anesthetic, at the very onset of reperfusion, markedly reduces myocardial injury following prolonged ischemia: anesthetic-induced PostC has been confirmed in several mammalian species including rat, mouse, rabbit, and human [1-8].
Positive_regulation (induced) of PostC in myocardium associated with ischemia and injury
8) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.29 Pain Relevance 0.45
Lu et al, in rat ventricular myocytes, showed that adenosine-induced PostC was mediated by stimulation of adenosine A1 receptors as suggested by abolition of cardioprotective effect of adenosine in presence of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) as A1 adenosine receptor antagonist [31].
Positive_regulation (mediated) of PostC in myocytes associated with adenocard and antagonist
9) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.07 Pain Relevance 0.80
Lu et al, in rat ventricular myocytes, showed that adenosine-induced PostC was mediated by stimulation of adenosine A1 receptors as suggested by abolition of cardioprotective effect of adenosine in presence of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) as A1 adenosine receptor antagonist [31].
Positive_regulation (induced) of PostC in myocytes associated with adenocard and antagonist
10) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.07 Pain Relevance 0.80
We have previously shown that opening of mitoKATP was an essential step of desflurane-induced PostC in human myocardium [7].
Positive_regulation (induced) of PostC in myocardium
11) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.07 Pain Relevance 0.39
However, only two studies suggested that ROS were involved in isoflurane-induced PostC in mouse myocardium in vivo [3], and in sevoflurane-induced PostC in isolated rat hearts [8].
Positive_regulation (induced) of PostC in hearts associated with isoflurane
12) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.16 Pain Relevance 0.63
Mechanisms involved in desflurane-induced PostC were studied in presence of desflurane 6%, because we have previously shown that 6% was effective to induce PostC in human myocardium, in vitro.7 In separate groups exposed to 6% desflurane during the first 5-min of reoxygenation in the presence of 150 ?
Positive_regulation (induced) of PostC in myocardium
13) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.22 Pain Relevance 0.13
The objectives of our study were to determine whether: 1) ROS generation, and adenosine and bradykinin receptor stimulation may be involved in desflurane-induced PostC, 2) adenosine and bradykinin given at the beginning of reoxygenation mimic PostC, 3) adenosine and bradykinin receptors' activation was followed by myocardial PostC via ROS production.


Spec (whether) Positive_regulation (induced) of PostC associated with adenocard and bradykinin
14) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.05 Pain Relevance 0.72
However, only two studies suggested that ROS were involved in isoflurane-induced PostC in mouse myocardium in vivo [3], and in sevoflurane-induced PostC in isolated rat hearts [8].
Positive_regulation (induced) of PostC in hearts associated with isoflurane
15) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.17 Pain Relevance 0.63
, and prevent the mPTP opening, in rat ventricular myocytes and in isolated rat heart [34,35] These signalling steps have been shown to be involved in ischemic and anesthetic induced PostC.
Positive_regulation (induced) of PostC in heart
16) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.12 Pain Relevance 0.52
The objectives of our study were to determine whether: 1) ROS generation, and adenosine and bradykinin receptor stimulation may be involved in desflurane-induced PostC, 2) adenosine and bradykinin given at the beginning of reoxygenation mimic PostC, 3) adenosine and bradykinin receptors' activation was followed by myocardial PostC via ROS production.


Positive_regulation (activation) of PostC associated with adenocard and bradykinin
17) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.17 Pain Relevance 0.74
Thus, it could be hypothesized that desflurane-induced PostC generates ROS via mitoKATP channels opening.
Positive_regulation (induced) of PostC
18) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.07 Pain Relevance 0.40
The present results show that both adenosine and B2 bradykinin receptors' stimulation are involved in desflurane-induced PostC.
Positive_regulation (induced) of PostC associated with adenocard and bradykinin
19) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.05 Pain Relevance 0.41

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