INT142695

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 3.75
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMGCR) oxidoreductase activity (HMGCR) endoplasmic reticulum (HMGCR)
peroxisome (HMGCR)
Anatomy Link Frequency
mononuclear cells 5
liver 3
plasma 1
monocytes 1
ovary 1
HMGCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 78 98.64 Very High Very High Very High
abdominal pain 4 82.96 Quite High
isoflurane 15 51.68 Quite High
anesthesia 16 50.80 Quite High
cva 1 40.48 Quite Low
COX2 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysgerminoma 87 99.68 Very High Very High Very High
Cancer 98 98.96 Very High Very High Very High
Disease 1 97.40 Very High Very High Very High
Renal Cancer 24 97.12 Very High Very High Very High
Cardiovascular Disease 6 94.32 High High
Weight Loss 12 94.16 High High
Epstein-barr Virus 18 90.40 High High
Disorder Of Lipid Metabolism 118 85.20 High High
Abdominal Pain 4 82.96 Quite High
Van Bogaert's Disease 16 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recent trials have suffered from high interference due to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) introduction, particularly in their placebo control groups.
Gene_expression (introduction) of 3-hydroxy-3-methylglutaryl coenzyme A reductase
1) Confidence 0.65 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17368273 Disease Relevance 0.50 Pain Relevance 0.08
Because of low TRC8 expression in the tumor, we anticipated that SREBP target genes, including HMGCR and SCD1 might be overexpressed.
Gene_expression (overexpressed) of HMGCR associated with cancer
2) Confidence 0.45 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.69 Pain Relevance 0
We also analyzed the expression of HMGCR and SCD1, two SREBP target genes potentially down-regulated by TRC8 in RCC cells, and of the housekeeping gene PGK (Fig. 7A).
Spec (analyzed) Gene_expression (expression) of HMGCR associated with renal cancer
3) Confidence 0.45 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.72 Pain Relevance 0
The purpose of this study was to evaluate the relationship between liver and mononuclear cell expression of HMG-CoA reductase and the LDL receptor in guinea pigs, a well established model for human cholesterol and lipoprotein metabolism.
Gene_expression (expression) of HMG-CoA reductase in mononuclear cell
4) Confidence 0.40 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
Thus we were not expecting an effect on LDL receptor or HMG-CoA reductase expression due to treatment [8].


Gene_expression (expression) of HMG-CoA reductase
5) Confidence 0.40 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.09 Pain Relevance 0.08
In contrast, we observed that SCD1 was strongly underexpressed while HMGCR was not affected in the dysgerminoma compared to normal ovary.
Neg (not) Gene_expression (affected) of HMGCR in ovary associated with dysgerminoma
6) Confidence 0.39 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.67 Pain Relevance 0
These correlations suggest that monocytes can be used in humans as an index for liver to assess diet and drug effects on the expression of HMG-CoA reductase and the LDL receptor.



Gene_expression (expression) of HMG-CoA reductase in monocytes
7) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The positive correlation found between the expression of the LDL receptor and HMG-CoA reductase in liver and mononuclear cells in the current study supports the measurement of the expression of these two ubiquitously distributed proteins in human mononuclear cells as a surrogate for hepatic cholesterol metabolism.


Gene_expression (expression) of HMG-CoA reductase in mononuclear cells
8) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.09 Pain Relevance 0
In agreement with these data, there were no significant differences in the expression of the LDL receptor or HMG-CoA reductase among groups.
Gene_expression (expression) of HMG-CoA reductase
9) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
Another study reported an increased expression of HMG-CoA reductase for human mononuclear cells in subjects consuming 10 g/d of psyllium for one month [4], results which are in agreement with hepatic HMG-CoA reductase activity being up-regulated in guinea pigs after psyllium consumption [17].
Gene_expression (expression) of HMG-CoA reductase in mononuclear cells
10) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.07 Pain Relevance 0
The relative values for mononuclear cell HMG-CoA reductase expression were 2.61 ± 2.33, 1.95 ± 1.85 and 1.39 ± 1.52 for control, low and high rapamacyn, respectively while the corresponding values for the liver were 1.54 ± 1.90, 0.81 ± 0.91 and 0.77 ± 1.04.
Gene_expression (expression) of HMG-CoA reductase in liver
11) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
In agreement with the finding of no changes in plasma LDL-C, there were also no differences for the expression of HMG-CoA reductase or the LDL receptor among groups.
Gene_expression (expression) of HMG-CoA reductase in plasma
12) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The current study provided an opportunity to study gene expression in both liver and mononuclear cells to validate mononuclear cells as surrogates of hepatic expression of HMG-CoA reductase and the LDL receptor.
Gene_expression (expression) of HMG-CoA reductase in mononuclear cells
13) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
A strong positive correlation was found between the expression of HMG-CoA reductase in the liver and in the mononuclear cells (r = 0.613, P < 0.01) (Figure 1, panel A).
Gene_expression (expression) of HMG-CoA reductase in mononuclear cells
14) Confidence 0.31 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The purpose of this study was to evaluate the relationship between liver and mononuclear cell expression of HMG-CoA reductase and the LDL receptor in guinea pigs, a well established model for human cholesterol and lipoprotein metabolism.
Gene_expression (expression) of HMG-CoA reductase in liver
15) Confidence 0.14 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The positive correlation found between the expression of the LDL receptor and HMG-CoA reductase in liver and mononuclear cells in the current study supports the measurement of the expression of these two ubiquitously distributed proteins in human mononuclear cells as a surrogate for hepatic cholesterol metabolism.


Gene_expression (expression) of HMG-CoA reductase in liver
16) Confidence 0.11 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.09 Pain Relevance 0
Ex vivo hepatic HMG-CoA reductase and fractional cholesterol synthesis rate in hamsters
Gene_expression (synthesis) of HMG-CoA reductase
17) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC385249 Disease Relevance 0.06 Pain Relevance 0.05
In presence of NaF, 2.5% and 5% Gl reduced HMG-CoA reductase 3.5- and 1.9-fold, respectively, relative to control.


Gene_expression (reduced) of HMG-CoA reductase
18) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC385249 Disease Relevance 0.65 Pain Relevance 0.11
HMG-CoA reductase activity was expressed as pmol of [14C] mevalonate produced per min per mg microsomal protein.
Gene_expression (expressed) of HMG-CoA reductase
19) Confidence 0.02 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.12 Pain Relevance 0

General Comments

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