INT142717

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 5 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Freckles 4 82.04 Quite High
Skin Cancer 1 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these in vitro studies, we believe that the result we observed for Val92Met could be attributed to impaired MC1R function, while, for Arg163Gln, other factors, e.g. effect of other loci, need to be considered.
Positive_regulation (attributed) of Negative_regulation (impaired) of MC1R associated with melanocortin 1 receptor
1) Confidence 0.47 Published 2007 Journal Pigment Cell Res. Section Abstract Doc Link 17371441 Disease Relevance 0.36 Pain Relevance 0.28

General Comments

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