INT142719

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.83
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
cytoplasm (Col1a1)
Anatomy Link Frequency
cartilage 2
neuroblast 1
lobe 1
Col1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 76 93.12 High High
Spinal cord 1 92.08 High High
Nicotine 6 89.36 High High
rheumatoid arthritis 50 89.24 High High
tail-flick 2 79.20 Quite High
Inflammation 70 77.52 Quite High
analgesia 2 76.08 Quite High
Antinociceptive 1 75.36 Quite High
antinociception 1 75.00 Quite High
metalloproteinase 4 54.08 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 16 99.78 Very High Very High Very High
Stress Fractures 159 99.76 Very High Very High Very High
Obesity 81 97.56 Very High Very High Very High
Nicotine Addiction 9 97.16 Very High Very High Very High
Sprains And Strains 7 94.00 High High
Arthritis 130 93.12 High High
Glaucoma 6 91.88 High High
Rheumatoid Arthritis 50 89.24 High High
Osteoporosis 41 88.12 High High
Endometriosis (extended) 6 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genotyping of 15 SNPs in the VDR, CTR, IL-6, COL1A1, COL1A2, and LRP5 genes
COL1A1 Binding (Genotyping) of
1) Confidence 0.34 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.27 Pain Relevance 0
The COL1A1 rs2586488 and COL1A2 rs3216902 SNPs were associated with stress fractures in a recessive model (Table 3), and the risk was increased in carriers of the LRP5 rs2277268 minor allele in comparison with non-carriers (OR = 2.72; 95% CI 1.10-6.73, p = 0.03).
COL1A1 Binding (associated) of associated with stress fractures
2) Confidence 0.34 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.76 Pain Relevance 0
The association of the phenotype with the COL1A1 haplotypes was not significant.
COL1A1 Binding (association) of
3) Confidence 0.34 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.51 Pain Relevance 0
In order to rule out that the disorganization of the collagen fibers was due to mechanical damaging during sectioning, 30 µm sections of the anterior prostate lobe were stained by immunofluorescence with antibodies recognizing Type I collagen and were evaluated by confocal microscopy in order to obtain a stack of images inside the intact tissue.
Type I collagen Binding (recognizing) of in lobe
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.06 Pain Relevance 0
After the mice had been killed, paws were collected for histology, one femur for bone mineral density (BMD) and sera for analyses of markers of bone resorption (RatLaps; type I collagen cross-links, bone formation (osteocalcin) and cartilage destruction (cartilage oligomeric matrix protein), and for the evaluation of antigen-specific and innate immune responsiveness.
type I collagen Binding (cross) of in cartilage associated with hypercalcemia
5) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175035 Disease Relevance 1.72 Pain Relevance 0.43
After the mice had been killed, paws were collected for histology, one femur for bone mineral density (BMD) and sera for analyses of markers of bone resorption (RatLaps; type I collagen cross-links, bone formation (osteocalcin) and cartilage destruction (cartilage oligomeric matrix protein), and for the evaluation of antigen-specific and innate immune responsiveness.
type I collagen Binding (links) of in cartilage associated with hypercalcemia
6) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175035 Disease Relevance 1.72 Pain Relevance 0.43
Significant differences in cytisine-sensitive, high affinity [(125)I]epibatidine binding site levels (alpha(4)beta(2)(*) subtypes), but not in (125)I-alpha-bungarotoxin binding (alpha(7)(*) subtypes), were observed.
I-alpha-bungarotoxin Binding (binding) of
7) Confidence 0.02 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17371806 Disease Relevance 0.25 Pain Relevance 0.59
Since type-1 collagen engages integrins, we used Collagenase-A to disrupt neuroblast interactions with the extra-cellular collagen matrix.
type-1 collagen Binding (engages) of in neuroblast
8) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0.03
-SMA, CTGF and collagen type I at concentrations of 1–20 ?
collagen type I Binding (concentrations) of
9) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.25 Pain Relevance 0

General Comments

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