INT142741

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 9.41
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Anatomy Link Frequency
plasma 4
epitheliums 1
hip 1
testes 1
fat 1
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 364 99.24 Very High Very High Very High
agonist 40 98.36 Very High Very High Very High
anesthesia 19 95.56 Very High Very High Very High
Neuropeptide 15 93.72 High High
isoflurane 7 90.76 High High
antagonist 21 86.28 High High
Pain 36 80.08 Quite High
rheumatoid arthritis 60 78.20 Quite High
Inflammation 14 77.08 Quite High
Peripheral nervous system 2 72.68 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 243 99.48 Very High Very High Very High
Coagulation Disorder 44 99.44 Very High Very High Very High
Myocardial Infarction 52 99.32 Very High Very High Very High
Sprains And Strains 374 99.16 Very High Very High Very High
Endometriosis (extended) 122 98.20 Very High Very High Very High
Obesity 282 98.16 Very High Very High Very High
Heart Disease 4 97.36 Very High Very High Very High
Weight Gain 8 96.52 Very High Very High Very High
Targeted Disruption 68 94.32 High High
Cancer 50 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, CD-1 males were shown to be E2-resistant when compared with C57Bl6 mice regarding effects on testes weight and spermatogenesis (Spearow et al. 1999).
Gene_expression (resistant) of E2 in testes
1) Confidence 0.31 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.61 Pain Relevance 0
Selection of doses for pubertal E2 challenge
Gene_expression (challenge) of E2
2) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.33 Pain Relevance 0
g E2/kg bw/day in CD-1 and 0.6 to 1.05 ?
Gene_expression (/) of E2
3) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.17 Pain Relevance 0
g E2/kg bw/day regarding both TEB density parameters (data not shown).
Gene_expression (/) of E2
4) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.79 Pain Relevance 0
g E2/kg bw/day (Steraloids Inc., Newport, RI) dissolved in 50% dimethylsulfoxide (DMSO; vehicle control; Sigma-Aldrich, St.
Gene_expression (/) of E2
5) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.27 Pain Relevance 0.22
Higher levels of E2 in the presence of progesterone upregulate E2 ?
Gene_expression (levels) of E2
6) Confidence 0.26 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.11 Pain Relevance 0.45
Plasma E2 concentrations were 8.03±1.53 pg/ml (control, n?
Gene_expression (concentrations) of E2 in Plasma
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
E2 could not be detected in Ovx+vehicle treated group.
Neg (not) Gene_expression (detected) of E2
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
E2 was dissolved at 10 mM in water-free ethanol, then diluted in RPMI 1640 medium to a concentration of 10 µM stored at ?
Gene_expression (dissolved) of E2
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
The results detected by ELISA confirmed that plasma E2 concentration in Ovx+E2 group mice was more than 4 times as much as that in virgin (control) mice, and almost the same as that in 4 weeks old MRL mice, and nearly the half of that in 18 weeks old MRL mice.
Gene_expression (concentration) of E2 in plasma
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
The results detected by ELISA confirmed that plasma E2 concentration in Ovx+E2 group mice was more than 4 times as much as that in virgin (control) mice, and almost the same as that in 4 weeks old MRL mice, and nearly the half of that in 18 weeks old MRL mice.
Gene_expression (concentration) of E2 in plasma
11) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
All animals were well owed to recover for two weeks and then received daily s. c. injections of either E2 (100 µg/kg/day) or CpG (1.2 mg/Kg/day) only or both which were dissolved in sesame oil or PBS every morning for 2 weeks.
Gene_expression (injections) of E2
12) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.10
Aromatase deficiency, during which E2 is not produced, results in the development of adiposity and obesity [66].
Gene_expression (produced) of E2 associated with obesity
13) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.31 Pain Relevance 0.03
Our hypothesis would be supported if the administration of drugs that reduce concentrations of serotonin in the plasma cause increases in plasma cholesterol despite consistent levels of E2.
Gene_expression (levels) of E2 in plasma associated with serotonin
14) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.00 Pain Relevance 0.25
Higher levels of E2 in the presence of progesterone upregulate E2 ?
Gene_expression (presence) of E2
15) Confidence 0.23 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.11 Pain Relevance 0.49
Similarly, kisspeptin/Kiss1 expression in the AVPV was described previously as reduced in the AVPV in the absence of E2 signaling of aromatase-deficient (ArKO) female mice and by ISH in female ER?
Gene_expression (signaling) of E2
16) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0 Pain Relevance 0
Similarly, kisspeptin/Kiss1 expression in the AVPV was described previously as reduced in the AVPV in the absence of E2 signaling of aromatase-deficient (ArKO) female mice and by ISH in female ER?
Neg (absence) Gene_expression (absence) of E2
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0 Pain Relevance 0
Accumulation of visceral fat occurs in females when E2 levels become sufficiently low.
Gene_expression (levels) of E2 in fat
18) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.42 Pain Relevance 0.04
In females, recent evidence suggests that physiological levels of E2 protect against heart attacks, while testosterone makes heart attacks more likely [90].
Gene_expression (levels) of E2 in heart associated with myocardial infarction
19) Confidence 0.21 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.14 Pain Relevance 0.21
In our study, the E2 effect was mimicked by PPT, a highly selective agonist of ER?
Gene_expression (effect) of E2 associated with agonist
20) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.12

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