INT142752

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 12.07
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
microglia 3
poly 2
plasma 1
intermediary 1
A20 1
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 570 100.00 Very High Very High Very High
chemokine 71 99.68 Very High Very High Very High
cytokine 402 99.40 Very High Very High Very High
cINOD 43 95.56 Very High Very High Very High
agonist 92 94.96 High High
Inflammatory response 83 92.32 High High
rheumatoid arthritis 217 91.36 High High
Intracerebroventricular 45 91.20 High High
Mechanotransduction 12 84.80 Quite High
ischemia 55 79.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 611 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 192 99.44 Very High Very High Very High
Infection 54 98.00 Very High Very High Very High
Disease 525 97.40 Very High Very High Very High
Mycobacterial Infection 2 97.36 Very High Very High Very High
Adhesions 19 96.84 Very High Very High Very High
Colitis 69 96.68 Very High Very High Very High
Immunization 60 96.68 Very High Very High Very High
Enteropathy 1 96.36 Very High Very High Very High
Autoimmune Disease 84 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, direct activation of MyD88 by endothelial mechanosensors, such as P2X4 ion channels (47) and platelet-EC adhesion molecule-1 (48) cannot be excluded.
Positive_regulation (activation) of MyD88 in platelet associated with adhesions
1) Confidence 0.66 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.47 Pain Relevance 0.29
Both MyD88-dependent and MyD88-independent pathways were required for maximal PMN recruitment and vascular permeability resulting from the combination of mechanical ventilation and poly(I:C) treatment.


Positive_regulation (required) of MyD88 in poly
2) Confidence 0.48 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.14 Pain Relevance 0.19
Both MyD88-dependent and MyD88-independent pathways were required for maximal PMN recruitment and vascular permeability resulting from the combination of mechanical ventilation and poly(I:C) treatment.


Positive_regulation (required) of MyD88 in poly
3) Confidence 0.48 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.14 Pain Relevance 0.19
Interestingly, a set of 37 genes including sprr1a was induced more strongly in MyD88(-/-) mice, and most of them are involved in the regulation of cellular replication.
Positive_regulation (induced) of MyD88
4) Confidence 0.48 Published 2007 Journal Physiol. Genomics Section Abstract Doc Link 17374847 Disease Relevance 0.48 Pain Relevance 0.19
MyD88 is a central mediator of this process with superoxide a key intermediary.
Positive_regulation (mediator) of MyD88 in intermediary
5) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.84 Pain Relevance 0.28
mRNA expression in MPSIIIB mice depended on TLR4 and MyD88.
Positive_regulation (depended) of MyD88
6) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.08 Pain Relevance 0
Although TLR2-MyD88 signaling is required in vivo, at concentrations relevant to the in vivo studies rhBCL2A1 does not directly activate TLR2 in vitro.
Positive_regulation (required) of MyD88
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.49 Pain Relevance 0.07
Results provided evidence that HS oligosaccharides primed microglial activation through TLR4 and MyD88 both in vitro and in the MPSIIIB mouse brain.
Positive_regulation (activation) of MyD88 in brain
8) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.79 Pain Relevance 0.17
These data indicate that the TLR4/MD-2 complex requires CD14 for the activation of MyD88-dependent signaling by S-LPS, but not by R-LPS.
Positive_regulation (activation) of MyD88-dependent
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.41 Pain Relevance 0.12
All of these receptors require the adaptor protein MyD88 for immediate response to LPS and initiate a bifurcated signal transduction cascade that culminates in altered gene transcription, primarily via NF-?
Positive_regulation (require) of MyD88
10) Confidence 0.37 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.17 Pain Relevance 0.07
Upon stimulation with LPS or TNF, a splice-variant of MyD88, MyD88s, can be induced which prevents activation of NF?
Positive_regulation (induced) of MyD88s
11) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.13 Pain Relevance 0.17
the adaptor molecule MyD88, activating a well-defined signal transduction
Positive_regulation (activating) of MyD88
12) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.72 Pain Relevance 0.30
42 plus LPS induction of MyD88, CD14, and TLR2 mRNA expression in microglia.
Positive_regulation (induction) of MyD88 in microglia
13) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.76 Pain Relevance 0.07
plus LPS stimulation of MyD88, CD14, and TLR2 expression by microglia,
Positive_regulation (stimulation) of MyD88 in microglia
14) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.44 Pain Relevance 0.17
-related synergistic induction of CD14, MyD88, and Toll-like receptor 2, molecules that play critical roles in neuroinflammatory conditions.
Positive_regulation (induction) of MyD88
15) Confidence 0.31 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2442897 Disease Relevance 0.88 Pain Relevance 0.25
This has also been observed for most TLRs, with the exception of TLR3 and TLR4 [34-37]; TLR3 does not utilise MyD88 for signal transduction while TLR4 recruits additional adaptor molecules that are responsible for MyD88 independent signalling.
Positive_regulation (responsible) of MyD88
16) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.32 Pain Relevance 0.10
Therefore, TRAM provides a mechanism that allows sequential activation of MyD88-dependent signalling while TLR4 is located in the plasma membrane, followed by TRIF-dependent signalling after TLR4 internalisation [64] (Figure 1).
Positive_regulation (activation) of MyD88-dependent in plasma
17) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.05 Pain Relevance 0.03
LPS specifically activates cluster of differentiation (CD) 14/toll-like receptor (TRL) 4 co-receptors, expressed on glia and especially microglia in brain, with subsequent increase in gene transcription mediated by a required adaptor protein, myeloid differentiation factor 88 (MyD88), and then a bifurcated signaling pathway that is dependent on nuclear factor-kappaB (NF-?
Positive_regulation (increase) of MyD88 in microglia
18) Confidence 0.29 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 1.18 Pain Relevance 0.09
The intracellular signalling cascade of IL-1 is similar to that of the MyD88-dependant TLR cascade discussed previously and involves the induction of IRAK1, IRAK4, MyD88 and transforming growth factor-activated kinase (TAK)1 [26].
Positive_regulation (induction) of MyD88
19) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.13 Pain Relevance 0.46
Activation of TLR4 by LPS can induce both TRIF and MyD88-dependent pathways.
Positive_regulation (induce) of MyD88-dependent
20) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.19 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox