INT142753

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 10.03
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) transport (Lcn2) extracellular space (Lcn2)
extracellular region (Lcn2)
Anatomy Link Frequency
neutrophils 3
chondrocytes 2
myeloid cells 2
microglia 2
Nasal 2
Lcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 5 100.00 Very High Very High Very High
dexamethasone 58 99.82 Very High Very High Very High
cINOD 7 97.72 Very High Very High Very High
Inflammation 385 97.06 Very High Very High Very High
antagonist 7 96.04 Very High Very High Very High
Inflammatory response 103 93.52 High High
cytokine 26 86.76 High High
chemokine 133 86.20 High High
anesthesia 33 70.16 Quite High
wide dynamic range 2 65.44 Quite High
Disease Link Frequency Relevance Heat
Metastasis 67 100.00 Very High Very High Very High
Colon Cancer 2 100.00 Very High Very High Very High
Sprains And Strains 242 99.86 Very High Very High Very High
Pancreatic Cancer 118 99.84 Very High Very High Very High
Salmonella Infection 30 99.82 Very High Very High Very High
Cancer 268 99.44 Very High Very High Very High
Bacterial Meningitis 19 99.44 Very High Very High Very High
Bacterial Respiratory Disease 31 98.76 Very High Very High Very High
Apoptosis 41 98.56 Very High Very High Very High
INFLAMMATION 501 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if the wild type produces Lcn2-resistant and sensitive Ent, sterile-filtered culture supernatants were collected from wild-type KPPR1 grown overnight in iron-limited M9 minimal media.
Gene_expression (produces) of Lcn2
1) Confidence 0.76 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.05 Pain Relevance 0
Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2).

Gene_expression (expression) of lipocalin 2 in Nasal associated with inflammation
2) Confidence 0.76 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2757716 Disease Relevance 0.32 Pain Relevance 0.12
Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2).

Gene_expression (expression) of Lcn2 in Nasal associated with inflammation
3) Confidence 0.76 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2757716 Disease Relevance 0.32 Pain Relevance 0.12
The respiratory tract secretes Lcn2 at basal levels and rapidly upregulates Lcn2 expression during colonization [4],[6].
Gene_expression (expression) of Lcn2 in respiratory tract
4) Confidence 0.76 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.04
These data indicate that mucosal sources of Lcn2 are sufficient to provide its antibacterial effects during colonization.


Gene_expression (sources) of Lcn2 associated with bacterial respiratory disease
5) Confidence 0.76 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.25 Pain Relevance 0.06
The effects of lipocalin 2 overexpression on chondrocyte proliferation (64%, P < 0.05) and collagen type X expression (8-fold, P < 0.05) were further exacerbated with the addition of 10(-6) M Dex.
Gene_expression (overexpression) of lipocalin 2 in chondrocyte associated with dexamethasone
6) Confidence 0.71 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0 Pain Relevance 0.42
Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.
Gene_expression (expression) of lipocalin 2 in chondrocytes associated with dexamethasone
7) Confidence 0.71 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 18381927 Disease Relevance 0.10 Pain Relevance 0.40
This synergistic effect may be explained by a further increase in lipocalin 2 expression with Dex treatment of transfected cells (45%, P < 0.05).
Gene_expression (expression) of lipocalin 2 associated with dexamethasone
8) Confidence 0.71 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0 Pain Relevance 0.41
Despite producing Lcn2, neutrophils likely inhibit K. pneumoniae by predominantly Lcn2-independent mechanisms based on the following observations.
Gene_expression (producing) of Lcn2 in neutrophils
9) Confidence 0.67 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.27 Pain Relevance 0.07
However, Salmonella infection induces Lcn2 production in the intestine, and the ability to utilize Gly-Ent confers a competitive advantage over an iroN mutant during intestinal inflammation [31].
Gene_expression (production) of Lcn2 in intestine associated with salmonella infection and inflammation
10) Confidence 0.67 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.25 Pain Relevance 0.05
To determine the effect of Lcn2 on bacterial colonization, we colonized mice that express or lack Lcn2 with K. pneumoniae mutants that express or lack Ent, Gly-Ent and the alternative siderophore Yersiniabactin (Ybt).
Neg (lack) Gene_expression (express) of Lcn2
11) Confidence 0.67 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.14 Pain Relevance 0.07
In contrast, the large intestine does not express basal Lcn2 despite the presence of huge numbers of colonizing bacteria [4].
Neg (not) Gene_expression (express) of Lcn2 in large intestine
12) Confidence 0.67 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.17 Pain Relevance 0.04
In the presence of neutrophils, colonization by wild-type K. pneumoniae is the same in Lcn2+/+ and Lcn2?
Gene_expression (same) of Lcn2 in neutrophils
13) Confidence 0.66 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.10
Also, lcn2 (lipocalin-2) and timp1 were represented within this cluster.
Gene_expression (represented) of lipocalin-2
14) Confidence 0.65 Published 2007 Journal Physiol. Genomics Section Abstract Doc Link 17374847 Disease Relevance 0.58 Pain Relevance 0.19
Proliferation in lipocalin 2-overexpressing cells was less than in control cells (49%, P < 0.05), and overexpression caused an increase in collagen type X expression (4-fold, P < 0.05).
Gene_expression (overexpressing) of lipocalin 2
15) Confidence 0.62 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.06 Pain Relevance 0.48
Briefly, E. coli strain BL-21 expressing plasmid-encoded mouse lipocalin 2 as a glutathione S-transferase fusion protein (a gift from J.
Gene_expression (expressing) of lipocalin 2 associated with sprains and strains
16) Confidence 0.59 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.16 Pain Relevance 0
A murine Lcn2 receptor, 24p3R, has been identified and is widely expressed in tissues including the lung and in lymphoid and myeloid cells [7].
Gene_expression (expressed) of Lcn2 in myeloid cells
17) Confidence 0.59 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.50 Pain Relevance 0.03
In mice, the nasal mucosa responds to Streptococcus pneumoniae colonization by increasing Lcn2 mRNA expression (65-fold) [6].
Gene_expression (mRNA expre) of Lcn2 in nasal mucosa associated with bacterial meningitis
18) Confidence 0.59 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.60 Pain Relevance 0
In line with these findings, we also observed reduced expression of the Macrophage receptor with collagenous structure (Marco) and Lipocalin 2 (Lcn2), two molecules with dual roles in apoptosis and de-ramification of activated microglia [52,53].


Gene_expression (expression) of Lcn2 in microglia associated with apoptosis
19) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.62 Pain Relevance 0.06
In line with these findings, we also observed reduced expression of the Macrophage receptor with collagenous structure (Marco) and Lipocalin 2 (Lcn2), two molecules with dual roles in apoptosis and de-ramification of activated microglia [52,53].


Gene_expression (expression) of Lipocalin 2 in microglia associated with apoptosis
20) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.62 Pain Relevance 0.06

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