INT142761

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.28
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 1
TAs (Mus musculus)
Pain Link Frequency Relevance Heat
cva 4 100.00 Very High Very High Very High
diclofenac 210 99.24 Very High Very High Very High
Dopamine 150 99.24 Very High Very High Very High
monoamine 9 99.04 Very High Very High Very High
rheumatoid arthritis 12 95.56 Very High Very High Very High
Inflammation 32 85.12 High High
cytokine 36 84.08 Quite High
anesthesia 5 72.60 Quite High
cINOD 36 50.00 Quite Low
ischemia 2 45.68 Quite Low
Disease Link Frequency Relevance Heat
Hemorrhage 4 100.00 Very High Very High Very High
Vasculitis 88 98.52 Very High Very High Very High
Neurological Disease 3 97.28 Very High Very High Very High
Rheumatoid Arthritis 12 95.56 Very High Very High Very High
Stress 43 95.48 Very High Very High Very High
Disease 17 92.00 High High
INFLAMMATION 33 85.12 High High
Sepsis 4 75.00 Quite High
Churg-strauss Syndrome 3 58.80 Quite High
Increased Venous Pressure Under Development 9 58.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In septic lungs, CI, NA, NI, ST, IAH, TAS, and ratios of NA/CA, NI/CI, and IAH/TAS were significantly increased compared with the control (P < 0.02).
Positive_regulation (increased) of TAS in lungs associated with cva
1) Confidence 0.40 Published 2007 Journal Am Surg Section Abstract Doc Link 17375779 Disease Relevance 0.58 Pain Relevance 0.39
Of the 25 TAS/TAC genes tested, TAC-1 [early growth responses 1 (EGR1)] was one of the most strongly upregulated genes commonly in the PBMCs of many vasculitis patients, as 96% of patients expressed this gene at 3–300-fold higher levels than healthy volunteers (Fig. 1A).
Positive_regulation (upregulated) of TAS associated with vasculitis
2) Confidence 0.27 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.02 Pain Relevance 0.09
mg/kg significantly increase serum TAS level, but exerted the reverse effect at the doses of (40?
Positive_regulation (increase) of TAS
3) Confidence 0.15 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.37 Pain Relevance 0.27
However, our data raised the question whether the enhanced extracellular concentrations of TAs following chronic DCF treatment might be associated with a risk of neurological disorders for patients taking DCF over a prolonged period, as TAs dysregulation has been linked to various psychiatric diseases (Lindemann and Hoener 2005).
Positive_regulation (enhanced) of TAs associated with neurological disease, disease and diclofenac
4) Confidence 0.03 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0.26 Pain Relevance 0.57
In response to DCF treatment the proportion of DOPAC and DA decreased, whereas the proportion of TAs (OCT, TYR, and PEA) increased.
Positive_regulation (increased) of TAs associated with dopamine and diclofenac
5) Confidence 0.03 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0 Pain Relevance 0.62
Although TAs also used to increase if their metabolism by monoamine oxidase enzyme were impeded, simultaneous DA accumulation in the effluent was not detected.
Positive_regulation (increase) of TAs associated with dopamine and monoamine
6) Confidence 0.03 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0.05 Pain Relevance 0.66

General Comments

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