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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 1.07

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isomerase activity (PPP2R4) protein folding (PPP2R4) nucleolus (PPP2R4)
ATPase activity (PPP2R4) nucleus (PPP2R4) cytoplasm (PPP2R4)
PPP2R4 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 13 99.98 Very High Very High Very High
Abeta 1 97.48 Very High Very High Very High
Eae 3 95.00 High High
Disease Link Frequency Relevance Heat
Hypothermia 4 100.00 Very High Very High Very High
Alzheimer's Dementia 2 97.00 Very High Very High Very High
Disease 5 88.04 High High
Cognitive Disorder 2 75.16 Quite High
Delirium 1 67.80 Quite High
Confusion 1 67.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that, regardless of the anesthetic used, anesthesia induced rapid and massive hyperphosphorylation of tau, rapid and prolonged hypothermia, inhibition of Ser/Thr PP2A (protein phosphatase 2A), but no changes in APP metabolism or Abeta (beta-amyloid peptide) accumulation.
Positive_regulation (induced) of Phosphorylation (hyperphosphorylation) of PP2A associated with hypothermia, anesthesia, alzheimer's dementia and abeta
1) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376970 Disease Relevance 1.04 Pain Relevance 1.07

General Comments

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