INT142787

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccdc88a) Golgi apparatus (Ccdc88a) endoplasmic reticulum (Ccdc88a)
plasma membrane (Ccdc88a)
Anatomy Link Frequency
brain 4
Ccdc88a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 99.08 Very High Very High Very High
withdrawal 6 98.32 Very High Very High Very High
addiction 6 95.40 Very High Very High Very High
opiate 4 94.96 High High
Nucleus accumbens 2 82.96 Quite High
amygdala 2 58.08 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 95.40 Very High Very High Very High
Morphine Dependence 2 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant changes in mRNA expression for Galpha subunits were observed in several brain areas during withdrawal, while the changes were much less evident or absent 2 h after the final drug injection.
Regulation (changes) of Transcription (expression) of Galpha in brain associated with withdrawal
1) Confidence 0.36 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17377204 Disease Relevance 0.08 Pain Relevance 0.83
Here we investigated changes in the mRNA expression of the main classes of G-protein alpha (Galpha) subunits in various brain regions in morphine-dependent rats.
Spec (investigated) Regulation (changes) of Transcription (expression) of Galpha in brain associated with morphine
2) Confidence 0.36 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17377204 Disease Relevance 0.10 Pain Relevance 0.76

General Comments

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