INT142788

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.28
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rgs19) biological_process (Rgs19)
Anatomy Link Frequency
brain 1
Rgs19 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 24 99.36 Very High Very High Very High
opiate 6 97.84 Very High Very High Very High
addiction 9 97.56 Very High Very High Very High
withdrawal 9 95.12 Very High Very High Very High
Nucleus accumbens 3 66.08 Quite High
amygdala 3 52.84 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 97.84 Very High Very High Very High
Morphine Dependence 3 47.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we investigated changes in the mRNA expression of the main classes of G-protein alpha (Galpha) subunits in various brain regions in morphine-dependent rats.
Transcription (expression) of G-protein alpha in brain associated with morphine
1) Confidence 0.32 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17377204 Disease Relevance 0.09 Pain Relevance 0.75
Does the presence of morphine counteract adaptive changes in expression of G-protein alpha subunits mRNA induced by chronic morphine treatment?
Transcription (expression) of G-protein alpha associated with morphine
2) Confidence 0.24 Published 2007 Journal Pharmacol Rep Section Title Doc Link 17377204 Disease Relevance 0.10 Pain Relevance 0.86
G-protein alpha-subunit mRNA expression was determined shortly following the conclusion of chronic morphine administration (2 h after the final dose) and during withdrawal (48 h after the final dose).
Spec (determined) Transcription (expression) of G-protein alpha associated with withdrawal and morphine
3) Confidence 0.24 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17377204 Disease Relevance 0.09 Pain Relevance 0.81

General Comments

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