INT142800

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 14.75
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
plasma 2
hepatocytes 1
fat 1
neurons 1
adipocytes 1
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 24 95.56 Very High Very High Very High
antagonist 7 77.48 Quite High
tolerance 26 77.16 Quite High
noradrenaline 28 75.72 Quite High
Angina 13 71.28 Quite High
Potency 3 68.40 Quite High
agonist 27 67.24 Quite High
Inflammation 42 64.80 Quite High
ischemia 4 63.00 Quite High
aspirin 6 62.80 Quite High
Disease Link Frequency Relevance Heat
Hypertriglyceridemia 26 100.00 Very High Very High Very High
Obesity 496 99.98 Very High Very High Very High
Hyperlipidemia 164 99.90 Very High Very High Very High
Body Weight 165 99.72 Very High Very High Very High
Disorder Of Lipid Metabolism 574 99.66 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

57 99.30 Very High Very High Very High
Targeted Disruption 65 98.94 Very High Very High Very High
Congenital Myasthenic Syndromes 22 98.88 Very High Very High Very High
Alzheimer's Dementia 13 98.26 Very High Very High Very High
Hyperlipoproteinemia Type Ii 320 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of apoB100-LDL of genes regulating fatty acid oxidation (CPT1, PPAR?)
Positive_regulation (induction) of apoB100-LDL
1) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.32 Pain Relevance 0.16
VLDL and apoB48-containing lipoproteins had no effect on lipolysis, indicating that the interaction with adipocytes requires the LDLR.
Positive_regulation (requires) of LDLR in adipocytes associated with obesity
2) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.85 Pain Relevance 0.09
Patients who had inherited LDLR gene mutations were subjected to an aggressive surgical intervention involving partial hepatectomy to obtain the patient's own hepatocytes for ex vivo gene transfer with a replication deficient LDLR-retroviral vector.
Positive_regulation (inherited) of LDLR gene in hepatocytes
3) Confidence 0.40 Published 2010 Journal Int Arch Med Section Abstract Doc Link PMC3016243 Disease Relevance 1.05 Pain Relevance 0
Body weights and WAT mass increased in LDLR-null mice on a high fat diet compared with low fat diet controls [22, 81].
Positive_regulation (increased) of LDLR in fat associated with body weight and obesity
4) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.60 Pain Relevance 0
activation in male LDLR-deficient mice.

3.3.

Positive_regulation (activation) of LDLR
5) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.04 Pain Relevance 0
Reversal of hypercholesterolaemia was demonstrated in LDLR-/- mice fed with a high cholesterol diet after intraportal vascular injection of 1 × 1012 AAV-2 vector particles encoding the murine VLDLR driven by the CMV enhanced chicken ?
Positive_regulation (demonstrated) of LDLR associated with cytomegalovirus infection and hyperlipidemia
6) Confidence 0.34 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.59 Pain Relevance 0
Berberine could increase the transcriptional activity of LDLR promoter and it involved the JNK pathway, reducing serum LDL [11].
Positive_regulation (increase) of LDLR
7) Confidence 0.33 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.47 Pain Relevance 0
Treatment of hyperlipidemic hamsters with berberine reduced serum cholesterol by 40% and LDL-cholesterol by 42%, with a 3.5-fold increase in hepatic LDLR mRNA, and a 2.6-fold increase in hepatic LDLR protein [19].
Positive_regulation (increase) of LDLR
8) Confidence 0.33 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.27 Pain Relevance 0
Treatment of hyperlipidemic hamsters with berberine reduced serum cholesterol by 40% and LDL-cholesterol by 42%, with a 3.5-fold increase in hepatic LDLR mRNA, and a 2.6-fold increase in hepatic LDLR protein [19].
Positive_regulation (increase) of LDLR
9) Confidence 0.29 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.28 Pain Relevance 0
Statins inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, resulting in increased LDLr density with decreases in LDL, IDL, and VLDL particle synthesis (Farnier 1998; Segrest et al 2000).
Positive_regulation (increased) of LDLr associated with disorder of lipid metabolism
10) Confidence 0.24 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.92 Pain Relevance 0.03
The prevalence of hoFH is about 1 per million of the population (but slightly higher in populations with increased LDL-R mutation gene frequency), and often results from consanguinity.
Positive_regulation (increased) of LDL-R
11) Confidence 0.21 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.76 Pain Relevance 0
clearance via apoE receptors is also supported by the significant increase in amyloid deposition observed in transgenic APP mice deficient in the RAP gene [120], which has increased levels of several LDLR family members [121,122].
Positive_regulation (increased) of LDLR associated with targeted disruption and alzheimer's dementia
12) Confidence 0.19 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.53 Pain Relevance 0
After cholesterol is synthesised in astrocytes, it is released through ABCA1 and packaged into lipoprotein particles resembling HDL, which in turn are then taken up into neurons through the recognition of ApoE by a variety of lipoprotein receptors such as LDLR, LRP and the ApoE receptor.
Positive_regulation (variety) of LDLR in neurons associated with disorder of lipid metabolism
13) Confidence 0.18 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.10 Pain Relevance 0.03
The prevalence of heFH is about 1 per 500 of the population (up to 1:60–1:80 in populations with increased LDL-R mutation gene frequency such as French Canadians, Southern Afrikaners, and Lebanese).
Positive_regulation (increased) of LDL-R
14) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.92 Pain Relevance 0
In heFH, the presence of one abnormal LDL-R allele is associated with approximately 50% loss of LDL-R activity and two fold increase in plasma levels of LDL-C.
Positive_regulation (increase) of LDL-R in plasma
15) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.81 Pain Relevance 0
In hoFH patients, the presence of two abnormal LDL-R alleles is associated with approximately 100% loss of LDL-R activity and several-fold increases in plasma levels of LDL-C.
Positive_regulation (increases) of LDL-R in plasma
16) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.78 Pain Relevance 0
The agrin-dependent activation of MuSK through the low-density lipoprotein receptor (LDLR)-related protein (Lrp4) (8,9) is essential for the induction of presynaptic and postsynaptic differentiation, including the clustering of AChRs and rapsyn (10).
Positive_regulation (activation) of low-density lipoprotein receptor
17) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.66 Pain Relevance 0
In a group of 543 healthy, middle-aged men the C genotype was associated with elevated levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B (Apo B).
Positive_regulation (elevated) of low-density lipoprotein associated with disorder of lipid metabolism
18) Confidence 0.06 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.76 Pain Relevance 0.03
Incubation of PBMCs for 7 days with benidipine (0.01-1 micromol/l) significantly increased the number of Dil-Ac-LDL+/fluorescein isothiocyanate-lectin (FITC-Lectin)+ cells.
Positive_regulation (increased) of Dil-Ac-LDL
19) Confidence 0.03 Published 2006 Journal Hypertens. Res. Section Abstract Doc Link 17378377 Disease Relevance 0.14 Pain Relevance 0.07
At this point of time, the combination of simvastatin with niacin ER is an effective treatment of the specific components of dyslipidemia, namely improving the profiles of elevated TG and LDL-cholesterol and low levels of HDL-cholesterol.



Positive_regulation (elevated) of LDL-cholesterol associated with hypertriglyceridemia and disorder of lipid metabolism
20) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.87 Pain Relevance 0.07

General Comments

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