INT14281

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 1990
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 44
Total Number 47
Disease Relevance 34.19
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
reticulum 3
hepatocytes 2
apoptotic cell 2
plasma 1
liver 1
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 380 100.00 Very High Very High Very High
Crohn's disease 204 99.84 Very High Very High Very High
cytokine 43 98.80 Very High Very High Very High
sodium channel 2 94.36 High High
Inflammatory stimuli 20 93.00 High High
tetrodotoxin 1 75.00 Quite High
depression 90 73.48 Quite High
ischemia 30 73.32 Quite High
Hippocampus 58 68.00 Quite High
nMDA receptor antagonist 10 64.88 Quite High
Disease Link Frequency Relevance Heat
Stress 959 100.00 Very High Very High Very High
Rheumatoid Arthritis 380 100.00 Very High Very High Very High
Shock 30 100.00 Very High Very High Very High
Disease 443 99.84 Very High Very High Very High
Malaria 450 99.72 Very High Very High Very High
Death 369 99.46 Very High Very High Very High
Infection 749 99.38 Very High Very High Very High
Inflammatory Bowel Disease 48 99.26 Very High Very High Very High
Apoptosis 369 99.24 Very High Very High Very High
Adhesions 21 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Gene_expression (expression) of Hspa5 associated with stress, aging, shock and sprains and strains
1) Confidence 0.63 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.74 Pain Relevance 0.06
Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of MCP-1 induction and NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine-induced activation of NF-kappaB.
Gene_expression (transfection) of GRP78 associated with cytokine
2) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.32 Pain Relevance 0.18
To evaluate whether NV virus infection of microglia induced ER stress only in the context of the brain, microglial enriched fractions derived from FrCasE-, F43- and mock-infected mice (14 dpi) were examined by Taqman real-time quantitative RT-PCR to assess BiP and CHOP RNA expression levels.
Gene_expression (expression) of BiP in brain associated with stress and infection
3) Confidence 0.53 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.43 Pain Relevance 0
was increased concomitantly with the increases in the expression of BiP and CHOP proteins, even through p-eIF2?
Gene_expression (expression) of BiP
4) Confidence 0.51 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.88 Pain Relevance 0
Results from the present study indicated that levels of the putative oxidative stress marker TBARS were increased, while expression of GRP78 remained unchanged in the liver of P.berghei-infected DBA-2 mice.
Gene_expression (expression) of GRP78 in liver associated with stress
5) Confidence 0.44 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.92 Pain Relevance 0
Although being considered a marker of ER stress, GRP78 over-expression is in fact a homeostatic response that protects the cell against damage caused by ER dysfunction or stress.
Gene_expression (over) of GRP78 associated with stress
6) Confidence 0.44 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.30 Pain Relevance 0
The effects of malaria on TBARS and GRP78 expression were similar to the effects of menadione, a pro-oxidant agent non-inducer of CYP2a5, and contrasted with the effects of pyrazole, a prototypical inducer of CYP2a5.
Gene_expression (expression) of GRP78 associated with malaria
7) Confidence 0.44 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.95 Pain Relevance 0
Kirby and coworkers suggested that inducers of CYP2a5 have in common the property of causing oxidative injury to endoplasmic reticulum (ER), thereby producing an overexpression of GRP78 in hepatocytes [8,9].
Gene_expression (producing) of GRP78 in hepatocytes associated with injury
8) Confidence 0.44 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.98 Pain Relevance 0.11
On the other hand, we found that staurosporine, which mediates mitochondrial dysfunctions resulting in apoptotic cell death, did not induce any increases in BiP and CHOP proteins in RGC-5 [unpublished data].
Gene_expression (proteins) of BiP in apoptotic cell associated with apoptosis and death
9) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.16 Pain Relevance 0
We found (a) that NMDA induced BiP proteins in the retina at 12 h after its injection (on the basis of immunoblots), and (b) that, NMDA induced both BiP and CHOP in the retina (especially within retinal ganglion cells and INL) at 12 h after its injection (on the basis of our immunostaining results).
Gene_expression (proteins) of BiP in retina associated with ganglion cysts
10) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.08 Pain Relevance 0.07
Finally, in order to assess the level of ER-stress in acinar cells, the expression of the principal regulatory components and markers of ER-stress including BiP, Chop, and the spliced form of Xbp1 (Xbp1-s) were examined.
Gene_expression (expression) of BiP in acinar cells associated with stress
11) Confidence 0.44 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.56 Pain Relevance 0
At P14-19, the average fold difference (± s.e.m., sample size) in mutants as compared to wild-type littermates was as follows: BiP, 1.21 (± 0.17, n = 7); Chop, 0.93 (± 0.22, n = 14); Xbp1-s, 1.15 (± 0.17, n = 11).
Gene_expression (follows) of BiP
12) Confidence 0.43 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.65 Pain Relevance 0
BIP-4 epitope can be detected on both human peripheral blood and murine splenic mononuclear cells.
Gene_expression (detected) of BIP-4 in mononuclear cells
13) Confidence 0.41 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 1690753 Disease Relevance 0 Pain Relevance 0.16
Levels of GRP78 and CHOP were similar in Hr expressing cells and mock transfected cells (supplementary data figure S2).
Gene_expression (Levels) of GRP78
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.45 Pain Relevance 0
To determine if the early stages of the ER stress response was affected by Hr expression, levels of the protein chaperone GRP78 and the transcription factor CHOP were examined in COS cells treated with tunicamycin.
Spec (examined) Gene_expression (levels) of GRP78 associated with stress
15) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.55 Pain Relevance 0
The expressions of glucose-regulated protein 78(GRP78)/BiP, the phosphorylated form of eukaryotic initiation factor 2?
Gene_expression (expressions) of BiP
16) Confidence 0.40 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2652022 Disease Relevance 0.87 Pain Relevance 0
Treatment with tunicamycin induced apoptotic cell death in RGC-5 and also induced production of ER stress-related proteins (BiP, the phosphorylated form of eIF2?
Gene_expression (production) of BiP in apoptotic cell associated with stress, apoptosis and death
17) Confidence 0.40 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2652022 Disease Relevance 1.25 Pain Relevance 0
However, we found no differences in the relative levels of Bcl-2 and BiP in mutant and wild-type tenocytes (Supplementary Material, Fig.
Gene_expression (levels) of BiP
18) Confidence 0.39 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.54 Pain Relevance 0
Although being considered a marker of ER stress, GRP78 over-expression is in fact a homeostatic response that protects the cell against damage caused by ER dysfunction or stress.
Gene_expression (expression) of GRP78 associated with stress
19) Confidence 0.34 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.31 Pain Relevance 0
Additionally, the present study investigated whether the induction of CYP2a5 activity was associated with ER dysfunction (GRP78 protein overexpression), enhanced haem metabolism (HO-1 induction) and oxidative stress.
Gene_expression (overexpression) of GRP78 protein associated with stress
20) Confidence 0.34 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.66 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox