INT142815

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
muscle 2
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 43 100.00 Very High Very High Very High
Kinase C 72 99.84 Very High Very High Very High
Pain 24 99.04 Very High Very High Very High
Action potential 1 97.88 Very High Very High Very High
ASIC 2 96.92 Very High Very High Very High
agonist 37 89.44 High High
qutenza 1 77.68 Quite High
headache 1 73.72 Quite High
Migraine 1 73.32 Quite High
nociceptor 1 24.24 Low Low
Disease Link Frequency Relevance Heat
Pain 27 99.04 Very High Very High Very High
Ganglion Cysts 10 93.48 High High
Acidosis 1 89.68 High High
Migraine Disorders 1 73.72 Quite High
Death 2 58.64 Quite High
Nociception 6 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Hepatitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence against a control of P2X receptor channel function by PKC-mediated phosphorylation
Regulation (control) of Regulation (function) of P2X associated with kinase c
1) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.27
Close to the FT motif is a nearby conserved lysine residue that has been shown to be involved in regulating ATP potency (Lys190 in P2X1 and Lys188 in P2X2 that when mutated to alanine resulted in ?
Regulation (involved) of Regulation (regulating) of P2X2 associated with potency
2) Confidence 0.14 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0 Pain Relevance 0.39
This study provides evidence that muscle pH may be important in modulating P2X and TRPV1 responsiveness in exercising muscle.
Regulation (modulating) of Regulation (responsiveness) of P2X in muscle
3) Confidence 0.04 Published 2007 Journal J. Appl. Physiol. Section Abstract Doc Link 17379752 Disease Relevance 0.09 Pain Relevance 0.24
However, their role in P2X regulation or the transmission of pain signals remains unclear.


Regulation (role) of Regulation (regulation) of P2X associated with pain
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.60 Pain Relevance 0.43

General Comments

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