INT14282

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Context Info
Confidence 0.23
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.87
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (INA)
Anatomy Link Frequency
cardiomyocytes 2
nerve 1
INA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 3 100.00 Very High Very High Very High
local anesthetic 2 99.78 Very High Very High Very High
agonist 7 99.36 Very High Very High Very High
Pain 6 98.88 Very High Very High Very High
lidocaine 19 96.76 Very High Very High Very High
tetrodotoxin 13 96.60 Very High Very High Very High
addiction 6 91.96 High High
Action potential 82 91.32 High High
nociceptor 2 86.00 High High
unmyelinated 1 83.48 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 7 100.00 Very High Very High Very High
Pain 6 98.88 Very High Very High Very High
Asphyxia 1 82.76 Quite High
Dentin Sensitivity 1 79.60 Quite High
Neuroblastoma 2 75.00 Quite High
Heart Disease 1 64.08 Quite High
Cardiovascular Disorder Under Development 8 50.00 Quite Low
Arrhythmia Under Development 18 5.00 Very Low Very Low Very Low
Syndrome 16 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Confirming previous reports suggesting that metoprolol appears to have little or no local anesthetic activity, INa was not affected by metoprolol at concentrations up to 100 microM during voltage-clamp pulses applied at less than 1 Hz when holding potential was negative to -110 mV.
Neg (not) Regulation (affected) of INa associated with local anesthetic
1) Confidence 0.23 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1690800 Disease Relevance 0 Pain Relevance 0.21
INa was modulated by Na+ channel agonists such as toxin AsV from Anemonia sulcata and veratridine, which slowed current kinetics dramatically.
Regulation (modulated) of INa associated with agonist
2) Confidence 0.23 Published 1997 Journal Circ. Res. Section Abstract Doc Link 9048658 Disease Relevance 0.06 Pain Relevance 0.49
Adrenaline was used to study the differential effect of adrenaline-induced ischemia on intradental A-delta nerve activity (INA) and the concomitant sharp pain, as well as on the detection threshold for monopolar electrical stimulation.
Regulation (effect) of INA in nerve associated with pain and ischemia
3) Confidence 0.22 Published 1999 Journal Endod Dent Traumatol Section Abstract Doc Link 10219148 Disease Relevance 0.66 Pain Relevance 0.49
INa was not affected by 10 nM, was reduced (65%) by 100 nM, and not completely abolished (92%) by 300 nM tetrodotoxin (TTX).
Neg (not) Regulation (affected) of INa associated with tetrodotoxin
4) Confidence 0.20 Published 1997 Journal Glia Section Abstract Doc Link 9034832 Disease Relevance 0.15 Pain Relevance 0.62
Furthermore, intracellular Ca2+ and Na+ levels are very sensitive to INaK and INaCa, which supports our results obtained in virtual human cardiomyocytes.
Regulation (sensitive) of INaCa in cardiomyocytes
5) Confidence 0.14 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.30
Furthermore, intracellular Ca2+ and Na+ levels are very sensitive to INaK and INaCa, which supports our results obtained in virtual human cardiomyocytes.
Regulation (sensitive) of INaK in cardiomyocytes
6) Confidence 0.14 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.30

General Comments

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