INT142827

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
neuronal 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 6 99.82 Very High Very High Very High
Kinase C 1 99.74 Very High Very High Very High
Desipramine 5 90.44 High High
alcohol 51 79.88 Quite High
fluoxetine 1 67.84 Quite High
monoamine 2 57.20 Quite High
Central nervous system 15 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 81 90.48 High High
Toxicity 26 81.64 Quite High
Neurodegenerative Disease 2 66.04 Quite High
Congenital Anomalies 5 59.24 Quite High
Apoptosis 5 27.40 Quite Low
Cognitive Disorder 5 20.24 Low Low
Poisoning 24 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the antidepressants had any effect on CREB expression, nor on the accumulation of cyclic AMP.
Regulation (effect) of Gene_expression (expression) of CREB associated with antidepressant
1) Confidence 0.61 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.48
The importance of the CREB cascade for the development of orientation selectivity
Regulation (importance) of Gene_expression (cascade) of CREB
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.08
The non-cholinergic mechanisms of chlorpyrifos are not clear, but a possible target may be the signalling cascades involved in neuronal and hormonal inputs, including the cyclic-AMP – protein kinase A cascade, receptor signalling through protein kinase C, and direct effects on the expression and function of nuclear transcription factors mediating the switch from proliferation to differentiation, including c-fos, p53, AP-1, Sp1 and CREB (Ca2+/cAMP response element binding protein) (reviewed in [42]).
Regulation (effects) of Gene_expression (expression) of CREB in neuronal associated with kinase c
3) Confidence 0.06 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.39 Pain Relevance 0.05

General Comments

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