INT142829

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.37
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 6 99.92 Very High Very High Very High
Desipramine 5 96.56 Very High Very High Very High
fluoxetine 1 92.96 High High
cytokine 127 92.56 High High
agonist 51 77.88 Quite High
Inflammation 141 65.88 Quite High
Inflammatory response 14 61.56 Quite High
chemokine 5 52.00 Quite High
Central nervous system 23 50.00 Quite Low
monoamine 1 38.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 18 98.58 Very High Very High Very High
Cancer 147 98.44 Very High Very High Very High
Breast Cancer 125 96.36 Very High Very High Very High
Clear Cell Sarcoma 28 92.96 High High
Dermatofibroma 1 83.92 Quite High
Bladder Cancer 2 81.60 Quite High
Skin Cancer 4 80.84 Quite High
Lymphatic System Cancer 4 79.96 Quite High
Malignant Neoplastic Disease 8 79.20 Quite High
Pancreatic Cancer 1 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system.
Transcription (transcription) of cyclic AMP-response element-driven gene associated with antidepressant
1) Confidence 0.46 Published 2007 Journal Biochem. Pharmacol. Section Title Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.45
Wang et al [14] found the EWSR1-CREB1 chimeric transcript in 1 of 15 cases (~7%), a superficial tumor in the palm of a 66-year-old female.
Transcription (transcript) of CREB1 associated with cancer
2) Confidence 0.39 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.19 Pain Relevance 0
Mitogen- and stress-activated kinase 1 and 2 (MSK1/2), for example, can directly activate transcription factors such as cAMP-response element-binding protein (CREB), activating transcription factor 1 (ATF1), NF-?
Transcription (transcription) of cAMP-response element-binding protein associated with stress
3) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.16 Pain Relevance 0
Mitogen- and stress-activated kinase 1 and 2 (MSK1/2), for example, can directly activate transcription factors such as cAMP-response element-binding protein (CREB), activating transcription factor 1 (ATF1), NF-?
Transcription (transcription) of CREB associated with stress
4) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.16 Pain Relevance 0
The results suggest that ceramide-induced TLR4 signaling causes rapid phosphorylation/transcription of proteins involved in IRF3 and AP-1 transcription, including CREB, Fyn, PLC?
Transcription (transcription) of CREB
5) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0.03
MAPK can phosphorylate a variety of transcription factors, for example, ATF2, ELK1, CREB, MEF2C, CHOP/GADD153, and C/EBP?
Transcription (transcription) of CREB
6) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.12 Pain Relevance 0.22
Current studies using CGH and cDNA microarray analysis suggest a distinct signature of chromosome gains and losses and gene expression for the different classes of familial breast cancers (BRCA1, BRCA2, and BRCAX) compared to sporadic breast cancers.194 BRCA1 appears to interact with the p53 protein (leading to induction of the cell-cycle inhibitor p21Cip1/WAF1; Fig. 1)195 directly, with the RNA polymerase holoenzyme, with the transcription factor CREB, with two proteins termed BAP1 and BARD1, with ER?
Transcription (transcription) of CREB associated with breast cancer
7) Confidence 0.11 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.20 Pain Relevance 0
are also used by other nuclear transcription factors, including cAMP response element-binding protein (CREB) [88, 89], activator protein-1 (AP-1) [88], basic helix-loop-helix factors [90], signal transducers and activators of transcription (STATs) [91–93], and nuclear factor-?
Transcription (transcription) of cAMP response element-binding protein
8) Confidence 0.10 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.28 Pain Relevance 0.16
are also used by other nuclear transcription factors, including cAMP response element-binding protein (CREB) [88, 89], activator protein-1 (AP-1) [88], basic helix-loop-helix factors [90], signal transducers and activators of transcription (STATs) [91–93], and nuclear factor-?
Transcription (transcription) of CREB
9) Confidence 0.10 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.27 Pain Relevance 0.16

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