INT142830

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PDZK1IP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 6 99.56 Very High Very High Very High
Desipramine 5 97.88 Very High Very High Very High
monoamine 1 71.60 Quite High
fluoxetine 1 60.68 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After prolonged exposure (7-21 days) to a low concentration (200 nM) of the antidepressants, the enhanced E(max) values for SPAP production evident after 18 h were not maintained but CLOM and DMI induced a significant leftward shift in the isoprenaline EC50 after a 7-day period of treatment and this was sustained at the 21 day time point.
Regulation (values) of Gene_expression (production) of SPAP associated with desipramine and antidepressant
1) Confidence 0.11 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.51

General Comments

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