INT142831

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
T cells 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Desipramine 10 99.98 Very High Very High Very High
cytokine 34 98.56 Very High Very High Very High
antidepressant 12 89.36 High High
fluoxetine 2 77.36 Quite High
monoamine 2 42.64 Quite Low
Inflammation 30 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 79.76 Quite High
INFLAMMATION 31 5.00 Very Low Very Low Very Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Asthma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At nanomolar concentrations, CLOM and DMI increased expression of phospho-CREB (cyclic AMP response element binding protein).
Positive_regulation (increased) of Gene_expression (expression) of CREB associated with desipramine
1) Confidence 0.69 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.43
At nanomolar concentrations, CLOM and DMI increased expression of phospho-CREB (cyclic AMP response element binding protein).
Positive_regulation (increased) of Gene_expression (expression) of cyclic AMP response element binding protein associated with desipramine
2) Confidence 0.44 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.43
In contrast, overexpression of CREB in Jurkat T cells has been shown to downmodulate IFN-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB in T cells
3) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.24

General Comments

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