INT142847

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.09
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) extracellular space (IL6) aging (IL6)
extracellular region (IL6) nucleus (IRF6) DNA binding (IRF6)
Anatomy Link Frequency
bowel 1
IRF6 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 94 96.48 Very High Very High Very High
Inflammation 72 96.08 Very High Very High Very High
chemokine 4 83.60 Quite High
Inflammatory response 9 63.84 Quite High
metalloproteinase 5 50.00 Quite Low
spastic colon 4 50.00 Quite Low
Inflammatory mediators 2 35.60 Quite Low
sodium channel 5 5.00 Very Low Very Low Very Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 1 99.58 Very High Very High Very High
INFLAMMATION 87 96.08 Very High Very High Very High
Toxicity 1 83.20 Quite High
Necrosis 3 79.24 Quite High
Cancer 3 78.88 Quite High
Pre-term Labor 4 57.68 Quite High
Hypersensitivity 2 57.00 Quite High
Nicotine Addiction 6 56.32 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 53.56 Quite High
Functional Bowel Disorder 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Baseline TNF-alpha and LPS-induced TNF-alpha and IL-6 levels were significantly higher in patients reporting more than 3 bowel movements per day, urgency, watery stools, and pain associated with diarrhea compared with patients without these symptoms (all P < .05).
LPS Positive_regulation (induced) of IL-6 in bowel
1) Confidence 0.07 Published 2007 Journal Gastroenterology Section Body Doc Link 17383420 Disease Relevance 0 Pain Relevance 0
For example, the serpin antithrombin, has been shown to protect animals from LPS-induced septic shock and also to inhibit IL-6 induction by LPS [42,43].
LPS Positive_regulation (induction) of IL-6 associated with sepsis
2) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.52 Pain Relevance 0.24
from human gestational membranes in Transwell cultures [23], and show for the first time that releases of IL-6, IL-8 and IL-10 are stimulated by LPS in a side-specific manner from human gestational membranes.
LPS Positive_regulation (stimulated) of IL-6
3) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.22 Pain Relevance 0.24
and IL-6 were significantly increased by LPS compared to untreated controls (p < 0.001).
LPS Positive_regulation (increased) of IL-6
4) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
The LPS-induced MIF, IL-6, IL-8, and TNF-?
LPS Positive_regulation (induced) of IL-6
5) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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