INT142868

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0.55

plasma membrane (YY1, Oprd1) cell differentiation (YY1) intracellular (YY1) DNA binding (YY1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

YY1 (Homo sapiens) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 2 100.00 opiate 1 99.40 Analgesic 1 98.92 Lasting pain 1 97.28 tolerance 1 94.08 mu opioid receptor 1 90.36 Delta opioid receptors 1 86.00 agonist 1 68.36 antagonist 1 67.24

Disease Link Frequency Relevance Heat Pain 1 97.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers.

delta Positive_regulation (activation) of opioid receptor associated with opioid receptor

1) Confidence 0.01 Published 2007 Journal FASEB J. Section Title Doc Link 17384143 Disease Relevance 0.10 Pain Relevance 0.55

General Comments

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