INT142871

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.52
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 13 97.60 Very High Very High Very High
dexamethasone 8 91.76 High High
withdrawal 7 89.04 High High
bradykinin 10 88.60 High High
agonist 10 82.08 Quite High
Inflammation 25 80.40 Quite High
antagonist 22 70.32 Quite High
imagery 25 62.84 Quite High
cytokine 6 58.40 Quite High
methadone 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 165 99.86 Very High Very High Very High
Apoptosis 159 97.64 Very High Very High Very High
Cv Unclassified Under Development 12 97.60 Very High Very High Very High
Prostate Cancer 183 95.16 Very High Very High Very High
Colon Cancer 2 92.36 High High
Death 11 90.64 High High
Reperfusion Injury 32 90.20 High High
INFLAMMATION 30 80.40 Quite High
Targeted Disruption 10 77.20 Quite High
Skin Cancer 21 65.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, reduced expression of the apoptosis regulatory proteins FasL and Bad was found after a single administration of methadone.
Negative_regulation (reduced) of Gene_expression (expression) of Bad
1) Confidence 0.51 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.07 Pain Relevance 0
Reduced expression of BAD led to decreased proliferation of C4-2 cells (Fig. 1D, E).


Negative_regulation (Reduced) of Gene_expression (expression) of BAD
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.70 Pain Relevance 0.03
Thereby, it would not be surprising if cancer cells decrease BAD expression.
Negative_regulation (decrease) of Gene_expression (expression) of BAD associated with cancer
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.30 Pain Relevance 0.08
Calcitriol treatment also suppresses the phosphorylation of Akt and the expression of Bcl-2 family member BAD 64.
Negative_regulation (suppresses) of Gene_expression (expression) of BAD
4) Confidence 0.41 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.83 Pain Relevance 0.05
C4-2Luc xenografts with a reduced expression of BAD showed reduced tumor take and grew at a slower rate than cells with intact BAD expression.


Negative_regulation (reduced) of Gene_expression (expression) of BAD associated with cancer
5) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.90 Pain Relevance 0
Parallel to experiments with C4-2LucBAD cells, experiments were conducted with C4-2Luc cells in which endogenous BAD expression was inhibited by the shRNA approach.
Negative_regulation (inhibited) of Gene_expression (expression) of BAD
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.77 Pain Relevance 0.03
Therefore, we examined the effect of knocking down BAD expression on proliferation of these cells.
Spec (examined) Negative_regulation (knocking) of Gene_expression (expression) of BAD
7) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.63 Pain Relevance 0
We observed that B1KO had increased Bcl-2 (Figure 3A) and decreased Bad (Figure B) expressions compared to wild-type and B2KO animals.
Negative_regulation (decreased) of Gene_expression (expressions) of Bad
8) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.30 Pain Relevance 0.30

General Comments

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